Improvements of Atherosclerosis and Hepatic Oxidative Stress are Independent of Exercise Intensity in LDLr-/- Mice

dc.creatorTeodoro, Bruno Gonzaga
dc.creatorNatali, Antônio José
dc.creatorFernandes, Sílvio Anderson Toledo
dc.creatorMatta, Sérgio Luis Pinto da
dc.creatorPeluzio, Maria do Carmo Gouveia
dc.creatorSilva, Luciano Acordi da
dc.creatorPinho, Ricardo Aurino de
dc.date2017-11-07T17:29:02Z
dc.date2017-11-07T17:29:02Z
dc.date2012-04-10
dc.date.accessioned2023-09-27T21:25:24Z
dc.date.available2023-09-27T21:25:24Z
dc.identifier1880-3873
dc.identifierhttp://doi.org/10.5551/jat.11569
dc.identifierhttp://www.locus.ufv.br/handle/123456789/12841
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8960347
dc.descriptionCardiovascular diseases are the main causes of death in the Western world and are manifested by atherosclerosis. Depending on its intensity, regular aerobic exercise may be either beneficial or harmful to the atherosclerosis process. The aim of this study was to verify the effects of aerobic exercise training of different intensities on the profile of atherosclerotic lesions and serum lipid, and in the hepatic oxidative balance of low-density lipoprotein receptor-deficient (LDLr-/-) mice previously developed with atherosclerosis. All animals were submitted to a three-month high-fat and high-cholesterol diet regime. The animals were then randomly divided into no exercise (G1, n=9), low-intensity aerobic exercise (G2, n=10, 8 weeks of treadmill running, 30 min/day−1 at 8-10 m/min−1) and moderate-intensity aerobic exercise (G3, n=10, 8 weeks of treadmill running, 30 min/day−1 at 10-16m/min−1) groups. Serum total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG), and oxidative damage (protein carbonyls and lipid hydroperoxides) were measured. The activity of catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) in the liver tissue was assessed. G2 (0.015±0.005cm2) and G3 (0.014±0.001cm2) presented lower aortic fat deposition than G1 (0.039±0.005cm2). G2 and G3 exhibited higher HDL-C, TG and CAT activity, but lower lipid peroxidation and carbonyl protein than G1. SOD values were higher in G3 than G2 and G1, and GPx was higher in G2 than in G3 and G1. Our protocols of low- and moderate-intensity aerobic exercise training (30 min daily for 8 weeks) induced similar benefits in LDLr-/- mice with atherosclerosis.
dc.formatpdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherJournal of Atherosclerosis and Thrombosis
dc.relationV.19, N.10, p. 904-911, Abril 2012
dc.rightsOpen Access
dc.subjectAerobic exercise
dc.subjectPhysical activity
dc.subjectLipid profile
dc.subjectAtherosclerotic plaque
dc.subjectAntioxidant
dc.titleImprovements of Atherosclerosis and Hepatic Oxidative Stress are Independent of Exercise Intensity in LDLr-/- Mice
dc.typeArtigo


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