Physical exercise and regulation of intracellular calcium in cardiomyocytes of hypertensive rats

dc.creatorRodrigues, Joel Alves
dc.creatorPrímola-Gomes, Thales Nicolau
dc.creatorLeal, Tiago Ferreira
dc.creatorPedrosa, Danillo Laviola
dc.creatorRezende, Leonardo Mateus Teixeira
dc.creatorNatali, Antonio Jose
dc.creatorNóbrega, Clara
dc.creatorOliveira, Edilamar Menezes de
dc.date2022-08-08T18:25:18Z
dc.date2022-08-08T18:25:18Z
dc.date2018-08
dc.date.accessioned2023-09-27T21:25:07Z
dc.date.available2023-09-27T21:25:07Z
dc.identifier1678-4170
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2018001400172
dc.identifierhttps://locus.ufv.br//handle/123456789/29581
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8960289
dc.descriptionLink errado. Favor verificar.
dc.descriptionRegulation of intracellular calcium (Ca2+) in cardiomyocytes is altered by hypertension; and aerobic exercise brings benefits to hypertensive individuals. To verify the effects of aerobic exercise training on contractility and intracellular calcium (Ca2+) transients of cardiomyocytes and on the expression of microRNA 214 (miR-214) in the left ventricle of spontaneously hypertensive rats (SHR). SHR and normotensive Wistar rats of 16 weeks were divided into 4 groups -sedentary hypertensive (SH); trained hypertensive (TH); sedentary normotensive (SN); and trained normotensive (TN). Animals of the TH and TN groups were subjected to treadmill running program, 5 days/week, 1 hour/day at 60-70% of maximum running velocity for 8 weeks. We adopted a p ≤ 0.05 as significance level for all comparisons. Exercise training reduced systolic arterial pressure in hypertensive rats. In normotensive rats, exercise training reduced the time to 50% cell relaxation and the time to peak contraction and increased the time to 50% decay of the intracellular Ca2+ transients. In SHR, exercise increased the amplitude and reduced the time to 50% decay of Ca2+transients. Exercise training increased the expression of miR-214 in hypertensive rats only. The aerobic training applied in this study increased the availability of intracellular Ca2+ and accelerated the sequestration of these ions in left ventricular myocytes of hypertensive rats, despite increased expression of miR-214 and maintenance of cell contractility.
dc.formatpdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherArquivos Brasileiros de Cardiologia
dc.relationv. 111, n. 02, p. 172-179, ago. 2018
dc.rightsOpen Access
dc.subjectHypertension
dc.subjectExercise
dc.subjectRats
dc.subjectCalcium signaling
dc.subjectIntracellular calcium
dc.subjectSensing Proteins
dc.titlePhysical exercise and regulation of intracellular calcium in cardiomyocytes of hypertensive rats
dc.typeArtigo


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