Orbifloxacin: A Review of Properties, Its Antibacterial Activities, Pharmacokinetic/Pharmacodynamic Characteristics, Therapeutic Use, and Analytical Methods

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorCazedey, Edith Cristina Laignier
dc.creatorSalgado, Hérida Regina Nunes
dc.date2014-05-27T11:29:02Z
dc.date2016-10-25T18:47:59Z
dc.date2014-05-27T11:29:02Z
dc.date2016-10-25T18:47:59Z
dc.date2013-05-01
dc.date.accessioned2017-04-06T02:22:17Z
dc.date.available2017-04-06T02:22:17Z
dc.identifierCritical Reviews in Analytical Chemistry, v. 43, n. 2, p. 79-99, 2013.
dc.identifier1040-8347
dc.identifier1547-6510
dc.identifierhttp://hdl.handle.net/11449/75246
dc.identifierhttp://acervodigital.unesp.br/handle/11449/75246
dc.identifier10.1080/10408347.2012.746855
dc.identifierWOS:000327785900003
dc.identifier2-s2.0-84874490796
dc.identifierhttp://dx.doi.org/10.1080/10408347.2012.746855
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/895993
dc.descriptionOrbifloxacin is a third generation of fluoroquinolone that exhibits increased antibacterial activity against the Enterobacteriaceae, gram-negative and gram-positive bacteria, anaerobes, and mycobacteria. This drug was synthesized in 1987 and developed as a veterinary chemotherapeutic to use for livestock and domestic pets. Orbifloxacin is labeled for the treatment of skin, soft tissue, and urinary tract infections in dogs, and skin and soft tissue infections in cats, but in some countries, orbifloxacin has been given for the treatment of gastrointestinal and respiratory infections in cattle and swine and other animals. The in vitro activity and clinical efficacy of orbifloxacin against naturally occurring bacterial infections of the skin, ear, soft tissue, udder, and gastrointestinal and respiratory systems in different animals have been evaluated and good responses have been found. The minimum inhibitory concentration of orbifloxacin has been determined in various different pathogens and the results found in the literature are shown in this work. The pharmacokinetics of orbifloxacin has been evaluated by different routes of administration in goats, horses, pigs, rabbits, dogs, cats, camels, cattle, sheep, and fish. Orbifloxacin exhibits excellent pharmacokinetic parameters that suggest that this drug may have good clinical effects on various bacterial infections in these species. All methods described in the scientific literature for determination of orbifloxacin in different matrices were collected and discussed. © 2013 Copyright Taylor and Francis Group, LLC.
dc.languageeng
dc.relationCritical Reviews in Analytical Chemistry
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectanalytical methods
dc.subjectfluoroquinolones
dc.subjectOrbifloxacin
dc.subjectpharmacodynamics
dc.subjectpharmacokinetics
dc.subjectresistance
dc.subjectreview
dc.subjectveterinary drug
dc.subjectAnalytical method
dc.subjectAnti-bacterial activity
dc.subjectBacterial infections
dc.subjectClinical effects
dc.subjectClinical efficacy
dc.subjectEnterobacteriaceae
dc.subjectFluoroquinolones
dc.subjectGram-positive bacterium
dc.subjectIn-vitro
dc.subjectMinimum inhibitory concentration
dc.subjectNaturally occurring
dc.subjectPharmacokinetic parameters
dc.subjectScientific literature
dc.subjectSoft tissue
dc.subjectSoft tissue infections
dc.subjectTherapeutic use
dc.subjectThird generation
dc.subjectUrinary tract infections
dc.subjectVeterinary drugs
dc.subjectAgriculture
dc.subjectAnimals
dc.subjectElectric resistance
dc.subjectPharmacodynamics
dc.subjectRespiratory system
dc.subjectReviews
dc.subjectTissue
dc.subjectPharmacokinetics
dc.subjectantimicrobial activity
dc.subjectdose-response relationship
dc.subjectdrug
dc.subjectefficiency measurement
dc.subjectinhibition
dc.subjectreaction kinetics
dc.subjectAnimalia
dc.subjectBacteria (microorganisms)
dc.subjectBos
dc.subjectCamelidae
dc.subjectCanis familiaris
dc.subjectCapra hircus
dc.subjectCorynebacterineae
dc.subjectEquidae
dc.subjectNegibacteria
dc.subjectOryctolagus cuniculus
dc.subjectOvis aries
dc.subjectPosibacteria
dc.subjectSuidae
dc.titleOrbifloxacin: A Review of Properties, Its Antibacterial Activities, Pharmacokinetic/Pharmacodynamic Characteristics, Therapeutic Use, and Analytical Methods
dc.typeOtro


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