Implications of intrauterine protein malnutrition on prostate growth, maturation and aging

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorRinaldi, Jaqueline C.
dc.creatorJustulin Jr., Luis A.
dc.creatorLacorte, Livia M.
dc.creatorSarobo, Carolina
dc.creatorBoer, Patricia A.
dc.creatorScarano, Wellerson R.
dc.creatorFelisbino, Sergio L.
dc.date2014-05-27T11:28:56Z
dc.date2016-10-25T18:47:28Z
dc.date2014-05-27T11:28:56Z
dc.date2016-10-25T18:47:28Z
dc.date2013-04-19
dc.date.accessioned2017-04-06T02:20:46Z
dc.date.available2017-04-06T02:20:46Z
dc.identifierLife Sciences, v. 92, n. 13, p. 763-774, 2013.
dc.identifier0024-3205
dc.identifier1879-0631
dc.identifierhttp://hdl.handle.net/11449/75136
dc.identifierhttp://acervodigital.unesp.br/handle/11449/75136
dc.identifier10.1016/j.lfs.2013.02.007
dc.identifier2-s2.0-84875741455.pdf
dc.identifier2-s2.0-84875741455
dc.identifierhttp://dx.doi.org/10.1016/j.lfs.2013.02.007
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/895884
dc.descriptionAims Maternal malnutrition by low protein diet is associated with an increased incidence of metabolic disorders and decreased male fertility in adult life. This study aimed to assess the impact of maternal protein malnutrition (MPM) on prostate growth, tissue organization and lesion incidence with aging. Main methods Wistar rat dams were distributed into two groups, which were control (NP; fed a normal diet containing 17% protein) or a restricted protein diet (RP, fed a diet containing 6% protein) during gestation. After delivery all mothers and offspring received a normal diet. Biometrical parameters, hormonal levels and prostates were harvested at post-natal days (PND) 30, 120 and 360. Key findings MPM promoted low birth weight, decreased ano-genital distance (AGD) and reduced androgen plasma levels of male pups. Prostatic lobes from RP groups presented reduced glandular weight, epithelial cell height and alveolar diameter. The epithelial cell proliferation and collagen deposition were increased in RP group. Incidences of epithelial dysplasia and prostatitis were higher in the RP offspring than in the NP offspring at PND360. Significance Our findings show that MPM delays prostate development, growth and maturation until adulthood, probably as a result of low testosterone stimuli. The higher incidence of cellular dysplasia and prostatitis suggests that MPM increases prostate susceptibility to diseases with aging. © 2013 Elsevier Inc.
dc.languageeng
dc.relationLife Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAndrogen receptor
dc.subjectCollagen
dc.subjectEpithelial dysplasia
dc.subjectFetal programming
dc.subjectProstatitis
dc.subjectProtein malnutrition
dc.subjectandrogen
dc.subjectaging
dc.subjectandrogen blood level
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectano genital distance
dc.subjectcontrolled study
dc.subjectdysplasia
dc.subjectepithelial dysplasia
dc.subjectfemale
dc.subjectkwashiorkor
dc.subjectlow birth weight
dc.subjectmale
dc.subjectmaternal disease
dc.subjectmaternal protein malnutrition
dc.subjectmaturation
dc.subjectmeasurement
dc.subjectnonhuman
dc.subjectprogeny
dc.subjectprostate
dc.subjectprostatitis
dc.subjectrat
dc.subjectAging
dc.subjectAnimals
dc.subjectAnimals, Newborn
dc.subjectApoptosis
dc.subjectBody Weight
dc.subjectDiet, Protein-Restricted
dc.subjectEating
dc.subjectFemale
dc.subjectFetal Nutrition Disorders
dc.subjectMale
dc.subjectPregnancy
dc.subjectProstate
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectReceptors, Androgen
dc.subjectTestosterone
dc.subjectRattus norvegicus
dc.titleImplications of intrauterine protein malnutrition on prostate growth, maturation and aging
dc.typeOtro


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