Long-term effects of perinatal androgenization on reproductive parameters of male rat offspring androgenization and male rat reproduction

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorGuerra, M. T.
dc.creatorPerobelli, J. E.
dc.creatorSanabria, M.
dc.creatorAnselmo-Franci, J. A.
dc.creatorDe Grava Kempinas, W.
dc.date2014-05-27T11:28:50Z
dc.date2016-10-25T18:46:46Z
dc.date2014-05-27T11:28:50Z
dc.date2016-10-25T18:46:46Z
dc.date2013-04-03
dc.date.accessioned2017-04-06T02:19:37Z
dc.date.available2017-04-06T02:19:37Z
dc.identifierHormone and Metabolic Research, v. 45, n. 8, p. 586-592, 2013.
dc.identifier0018-5043
dc.identifier1439-4286
dc.identifierhttp://hdl.handle.net/11449/75057
dc.identifierhttp://acervodigital.unesp.br/handle/11449/75057
dc.identifier10.1055/s-0033-1341434
dc.identifierWOS:000322036400007
dc.identifier2-s2.0-84880513362
dc.identifierhttp://dx.doi.org/10.1055/s-0033-1341434
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/895808
dc.descriptionIt is known that during sex differentiation, fetal androgens are critical determinants of the male phenotype. Although testosterone is necessary for normal development of male sexual behavior, perinatal androgen treatment can result in disruption of normal male sexual reproduction. Pregnant Wistar rats were administered either corn oil (vehicle) or testosterone propionate at 0.2 mg/kg from gestational day 12 until the end of lactation and the reproductive function of male offspring was evaluated at 90 (adulthood) and 270 (middle age) days of age. Perinatal androgenization in the rat provoked a reduction in sperm production and reserves in adulthood that did not affect fertility and did not persist at more advanced ages, as shown by the results at post-natal day 270. If perinatal androgenization promotes similar effects in humans of reproductive age, the results of the present work can impact male reproduction health, given the less efficient spermatogenesis and lower sperm reserves in the human epididymis, compared to rodents. © Georg Thieme Verlag KG Stuttgart. New York.
dc.languageeng
dc.relationHormone and Metabolic Research
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectfertility
dc.subjectperinatal androgenization
dc.subjectrat male offspring
dc.subjectsexual behavior
dc.subjectsperm counts
dc.subjectcorn oil
dc.subjectestrogen
dc.subjectfollitropin
dc.subjectluteinizing hormone
dc.subjectprogesterone
dc.subjecttestosterone
dc.subjecttestosterone propionate
dc.subjectadulthood
dc.subjectandrogen therapy
dc.subjectanimal experiment
dc.subjectbody weight
dc.subjectcontrolled study
dc.subjectepididymis
dc.subjectestrogen blood level
dc.subjectfollitropin blood level
dc.subjectgestational age
dc.subjecthistopathology
dc.subjectlactation
dc.subjectluteinizing hormone blood level
dc.subjectmale fertility
dc.subjectnewborn
dc.subjectnonhuman
dc.subjectperinatal period
dc.subjectpriority journal
dc.subjectprogeny
dc.subjectprogesterone blood level
dc.subjectqualitative analysis
dc.subjectquantitative analysis
dc.subjectrat
dc.subjectreproduction
dc.subjectspermatogenesis
dc.subjecttestosterone blood level
dc.subjectRattus
dc.subjectRattus norvegicus
dc.subjectRodentia
dc.subjectZea mays
dc.titleLong-term effects of perinatal androgenization on reproductive parameters of male rat offspring androgenization and male rat reproduction
dc.typeOtro


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