Development and evaluation of praziquantel solid dispersions in sodium starch glycolate

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorChaud, Marco V.
dc.creatorLima, Andréa C.
dc.creatorVila, Marta M.D.C.
dc.creatorPaganelli, Maria O.
dc.creatorPaula, Fábio C.
dc.creatorPedreiro, Liliane N.
dc.creatorGremião, Maria P.D.
dc.date2014-05-27T11:28:49Z
dc.date2016-10-25T18:46:39Z
dc.date2014-05-27T11:28:49Z
dc.date2016-10-25T18:46:39Z
dc.date2013-04-01
dc.date.accessioned2017-04-06T02:19:14Z
dc.date.available2017-04-06T02:19:14Z
dc.identifierTropical Journal of Pharmaceutical Research, v. 12, n. 2, p. 163-168, 2013.
dc.identifier1596-5996
dc.identifier1596-9827
dc.identifierhttp://hdl.handle.net/11449/75036
dc.identifierhttp://acervodigital.unesp.br/handle/11449/75036
dc.identifier10.4314/tjpr.v12i2.5
dc.identifierWOS:000318672800005
dc.identifier2-s2.0-84876941339.pdf
dc.identifier2-s2.0-84876941339
dc.identifierhttp://dx.doi.org/10.4314/tjpr.v12i2.5
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/895787
dc.descriptionPurpose: To develop and characterize solid dispersions of praziquantel (PZQ) with sodium starch glycolate (SSG) for enhanced drug solubility. Methods: PZQ solid dispersion (SD) was prepared using co-precipitation method by solvent evaporation. The ratios of PZQ to SSG were 2:1, 1:1, 1:2, 1:3 (w/w). PZQ solubility was evaluated in purified water, and PZQ dissolution test was carried out in 0.1N HCl. Structural characterization of the dispersions was accomplished by x-ray diffraction (XRD) and infrared spectroscopy (FTIR) while the external morphology of the SDs, SSG and PZQ were studied by scanning electron microscopy (SEM). Mucoadhesion properties of the SD (1:3) and SSG, on mucin disks were examined using texture profile analysis. Results: The highest solubility was obtained with 1:3 solid dispersion, with PZQ solubility of 97.31 %, which is 3.65-fold greater than the solubility of pure PZQ and physical misture (PM, 1:3). XRD results indicate a reduction in PZQ crystallinity while infrared spectra showed that the functional groups of PZQ and SSG were preserved. SEM showed that the physical structure of PZQ was modified from crystalline to amorphous. The amount of PZQ in PM and SD (1:3) that dissolved in 60 min was 70 and 88 %, respectively, and these values increased to 76 and 96 %, respectively. The solid dispersion reduced the mucoadhesive property of the glycolate. Conclusion: Solid dispersion formulation using SSG is a good alternative approach for increasing the dissolution rate of PZQ. © Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria. All rights reserved.
dc.languageeng
dc.relationTropical Journal of Pharmaceutical Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCo-precipitation
dc.subjectDrug bioavailability
dc.subjectPraziquantel
dc.subjectSchistosomiasis
dc.subjectSodium starch glycolate
dc.subjectSolid dispersion
dc.subjecthydrochloric acid
dc.subjectmucin
dc.subjectpraziquantel
dc.subjectsolvent
dc.subjectstarch glycolate sodium
dc.subjectwater
dc.subjectcrystal structure
dc.subjectdispersion
dc.subjectdrug bioavailability
dc.subjectdrug release
dc.subjectdrug screening
dc.subjectdrug solubility
dc.subjectdrug structure
dc.subjectevaporation
dc.subjectin vitro study
dc.subjectinfrared spectroscopy
dc.subjectmucoadhesion
dc.subjectprecipitation
dc.subjectscanning electron microscopy
dc.subjectX ray diffraction
dc.titleDevelopment and evaluation of praziquantel solid dispersions in sodium starch glycolate
dc.typeOtro


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