An exploratory dimensional approach to premenstrual manifestation of obsessive-compulsive disorder symptoms: A multicentre study

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorMoreira, Luciana
dc.creatorBins, Helena
dc.creatorToressan, Ricardo
dc.creatorFerro, Cláudia
dc.creatorHarttmann, Thiago
dc.creatorPetribú, Kátia
dc.creatorJuruena, Mário Francisco
dc.creatordo Rosário, Maria Conceição
dc.creatorFerrão, Ygor Arzeno
dc.date2014-05-27T11:28:45Z
dc.date2016-10-25T18:46:01Z
dc.date2014-05-27T11:28:45Z
dc.date2016-10-25T18:46:01Z
dc.date2013-04-01
dc.date.accessioned2017-04-06T02:18:08Z
dc.date.available2017-04-06T02:18:08Z
dc.identifierJournal of Psychosomatic Research, v. 74, n. 4, p. 313-319, 2013.
dc.identifier0022-3999
dc.identifier1879-1360
dc.identifierhttp://hdl.handle.net/11449/74930
dc.identifierhttp://acervodigital.unesp.br/handle/11449/74930
dc.identifier10.1016/j.jpsychores.2012.12.004
dc.identifierWOS:000316586600008
dc.identifier2-s2.0-84875242022
dc.identifierhttp://dx.doi.org/10.1016/j.jpsychores.2012.12.004
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/895689
dc.descriptionObjective: In women with obsessive-compulsive disorder (OCD), symptom severity appears to fluctuate over the course of the menstrual cycle. The objective of this paper was to compare female OCD patients with and without premenstrual worsening of obsessive-compulsive symptoms (OCS), in terms of the clinical characteristics of OCD. Methods: This was a cross-sectional study involving 455 women with OCD, of whom 226 (49.7%) had experienced premenstrual OCS worsening and 229 (50.3%) had not (PMOCS-worse and PMOCS-same groups, respectively). Data were collected with the original and dimensional versions of the Yale-Brown Obsessive-Compulsive Scale, as well as with the Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI). Results: We found significant differences between the PMOCS-same and PMOCS-worse groups, the latter showing a higher frequency of suicidal ideation (P<.001), suicide attempts (P=.027), current use of selective serotonin reuptake inhibitors (P=.022), lifetime use of mood stabilisers (P=.015), and sexual/religious obsessions (P<.001; OR. =1.90), as well as higher scores on the BDI (P<.001) and BAI (P<.001). Conclusion: Underscoring the fact that OCD is a heterogeneous disorder, there appears to be a subgroup of female OCD patients in whom the premenstrual period is associated with a higher frequency of sexual/religious obsessions, depression, anxiety, and suicidality. This might be attributable to hormonal fluctuations. Further studies are warranted in order to investigate this hypothesis by evaluating such patients at different phases of the menstrual cycle, as well as measuring hormonal levels. © 2012 Elsevier Inc.
dc.languageeng
dc.relationJournal of Psychosomatic Research
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectLuteal phase
dc.subjectObsessive-compulsive symptoms
dc.subjectPremenstrual period
dc.subjectSymptom dimensions
dc.subjectmood stabilizer
dc.subjectserotonin uptake inhibitor
dc.subjectadult
dc.subjectBeck Depression Inventory
dc.subjectclinical feature
dc.subjectcross-sectional study
dc.subjectdisease severity
dc.subjectdrug use
dc.subjectfemale
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectobsessive compulsive disorder
dc.subjectpremenopause
dc.subjectreligion
dc.subjectsexual behavior
dc.subjectsuicidal ideation
dc.subjectYale Brown Obsessive Compulsive Scale
dc.subjectAdult
dc.subjectAntidepressive Agents
dc.subjectAnxiety
dc.subjectCross-Sectional Studies
dc.subjectDepression
dc.subjectFemale
dc.subjectHumans
dc.subjectMiddle Aged
dc.subjectObsessive-Compulsive Disorder
dc.subjectPremenstrual Syndrome
dc.subjectPsychiatric Status Rating Scales
dc.subjectSerotonin Uptake Inhibitors
dc.subjectSeverity of Illness Index
dc.subjectSuicide, Attempted
dc.titleAn exploratory dimensional approach to premenstrual manifestation of obsessive-compulsive disorder symptoms: A multicentre study
dc.typeOtro


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