Effects of sublethal dose of fipronil on neuron metabolic activity of africanized honeybees

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorRoat, Thaisa Cristina
dc.creatorCarvalho, Stephan M.
dc.creatorNocelli, Roberta C. F.
dc.creatorSilva-Zacarin, Elaine C. M.
dc.creatorPalma, Mario Sergio
dc.creatorMalaspina, Osmar
dc.date2014-05-27T11:28:44Z
dc.date2016-10-25T18:45:56Z
dc.date2014-05-27T11:28:44Z
dc.date2016-10-25T18:45:56Z
dc.date2013-04-01
dc.date.accessioned2017-04-06T02:17:47Z
dc.date.available2017-04-06T02:17:47Z
dc.identifierArchives of Environmental Contamination and Toxicology, v. 64, n. 3, p. 456-466, 2013.
dc.identifier0090-4341
dc.identifier1432-0703
dc.identifierhttp://hdl.handle.net/11449/74898
dc.identifierhttp://acervodigital.unesp.br/handle/11449/74898
dc.identifier10.1007/s00244-012-9849-1
dc.identifierWOS:000316344200011
dc.identifier2-s2.0-84880570437
dc.identifierhttp://dx.doi.org/10.1007/s00244-012-9849-1
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/895657
dc.descriptionFipronil is a neurotoxic insecticide that inhibits the gamma-aminobutyric acid receptor and can affect gustative perception, olfactory learning, and motor activity of the honeybee Apis mellifera. This study determined the lethal dose (LD50) and the lethal concentration (LC50) for Africanized honeybee and evaluated the toxicity of a sublethal dose of fipronil on neuron metabolic activity by way of histochemical analysis using cytochrome oxidase detection in brains from worker bees of different ages. In addition, the present study investigated the recovery mechanism by discontinuing the oral exposure to fipronil. The results showed that mushroom bodies of aged Africanized honeybees are affected by fipronil, which causes changes in metabolism by increasing the respiratory activity of mitochondria. In antennal lobes, the sublethal dose of fipronil did not cause an increase in metabolic activity. The recovery experiments showed that discontinued exposure to a diet contaminated with fipronil did not lead to recovery of neural activity. Our results show that even at very low concentrations, fipronil is harmful to honeybees and can induce several types of injuries to honeybee physiology. © 2012 Springer Science+Business Media New York.
dc.languageeng
dc.relationArchives of Environmental Contamination and Toxicology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectcytochrome c oxidase
dc.subjectfipronil
dc.subjectbrain
dc.subjectconcentration (composition)
dc.subjectdose-response relationship
dc.subjectecotoxicology
dc.subjecthoneybee
dc.subjectinhibition
dc.subjectinjury
dc.subjectinsecticide
dc.subjectlearning
dc.subjectmetabolism
dc.subjectneurology
dc.subjectphysiology
dc.subjectpollution exposure
dc.subjectsublethal effect
dc.subjectacute toxicity
dc.subjecthistochemistry
dc.subjectLC 50
dc.subjectLD 50
dc.subjectmitochondrion
dc.subjectnerve cell
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectApis mellifera
dc.subjectApis mellifera scutellata
dc.subjectApoidea
dc.subjectBasidiomycota
dc.titleEffects of sublethal dose of fipronil on neuron metabolic activity of africanized honeybees
dc.typeOtro


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