Splicing regulators and their roles in cancer biology and therapy

dc.creatorSilva, Maria Roméria da
dc.creatorMoreira, Gabriela Alves
dc.creatorSilva, Ronni Anderson Gonçalves da
dc.creatorBarbosa, Éverton de Almeida Alves
dc.creatorSiqueira, Raoni Pais
dc.creatorTeixera, Róbson Ricardo
dc.creatorAlmeida, Márcia Rogéria
dc.creatorSilva Júnior, Abelardo
dc.creatorFietto, Juliana Lopes Rangel
dc.creatorBressan, Gustavo Costa
dc.date2017-11-08T10:10:01Z
dc.date2017-11-08T10:10:01Z
dc.date2015-04-01
dc.date.accessioned2023-09-27T21:10:34Z
dc.date.available2023-09-27T21:10:34Z
dc.identifier2314-6133
dc.identifierhttp://dx.doi.org/10.1155/2015/150514
dc.identifierhttp://www.locus.ufv.br/handle/123456789/12854
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8955990
dc.descriptionAlternative splicing allows cells to expand the encoding potential of their genomes. In this elegant mechanism, a single gene can yield protein isoforms with even antagonistic functions depending on the cellular physiological context. Alterations in splicing regulatory factors activity in cancer cells, however, can generate an abnormal protein expression pattern that promotes growth, survival, and other processes, which are relevant to tumor biology. In this review, we discuss dysregulated alternative splicing events and regulatory factors that impact pathways related to cancer. The SR proteins and their regulatory kinases SRPKs and CLKs have been frequently found altered in tumors and are examined in more detail. Finally, perspectives that support splicing machinery as target for the development of novel anticancer therapies are discussed.
dc.formatpdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherBioMed Research International
dc.relationv. 2015, ID 150514, Apr. 2015
dc.rightsOpen Access
dc.subjectSplicing regulators
dc.subjectCancer
dc.subjectTherapy
dc.titleSplicing regulators and their roles in cancer biology and therapy
dc.typeArtigo


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