Cardiac remodeling induced by 13-cis retinoic acid treatment in acne patients

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorSoriano, Eline A.
dc.creatorGaiolla, Paula Schmidt Azevedo
dc.creatorMiot, Hélio Amante
dc.creatorMinicucci, Marcos Ferreira
dc.creatorPansani, Mariele C.
dc.creatorMatsubara, Luiz Shiguero
dc.creatorOkoshi, Katashi
dc.creatorZornoff, Leonardo Antonio Mamede
dc.creatorMatsubara, Beatriz Bojikian
dc.creatorPaiva, Sergio A.R.
dc.date2014-05-27T11:28:22Z
dc.date2016-10-25T18:44:16Z
dc.date2014-05-27T11:28:22Z
dc.date2016-10-25T18:44:16Z
dc.date2013-02-10
dc.date.accessioned2017-04-06T02:12:52Z
dc.date.available2017-04-06T02:12:52Z
dc.identifierInternational Journal of Cardiology, v. 163, n. 1, p. 68-71, 2013.
dc.identifier0167-5273
dc.identifier1874-1754
dc.identifierhttp://hdl.handle.net/11449/74573
dc.identifierhttp://acervodigital.unesp.br/handle/11449/74573
dc.identifier10.1016/j.ijcard.2011.05.048
dc.identifierWOS:000314100700019
dc.identifier2-s2.0-84873079591.pdf
dc.identifier2-s2.0-84873079591
dc.identifierhttp://dx.doi.org/10.1016/j.ijcard.2011.05.048
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/895336
dc.descriptionBackground: Currently, 13-cis-retinoic acid (13-cis-RA) is the most effective therapy for acne. Isotretinoin, a first-generation synthetic 13-cis-RA compound, is associated with numerous adverse effects. To investigate the cardiac effects of 13-cis-RA, acne patients receiving 13-cis-RA were studied. Methods: Twenty male patients with acne were enrolled in the study. Patients were treated with a dose of 0.5 mg/kg/d of isotretinoin. All participants were assessed prior to treatment and after 10 weeks of therapy with Doppler-echocardiogram. Results: Patients showed reductions in right atrium vertical diameter, left atrium longitudinal diameter, left atrium volume and left ventricular diastolic diameter over the course of treatment. Significant increases in interventricular septum diastolic thickness, posterior wall diastolic thickness, relative wall relative thickness and left ventricle (LV) mass were observed. The LV mass index showed an increase in ventricular mass and a decrease in the cavity size. Examining LV systolic function, a decrease was observed for the cardiac index. Conclusion: In this study, 10 weeks of 13-cis-RA therapy at a dose of 0.5 mg/kg/d was found to promote concentric-type heart remodeling due to the occurrence of two associated events: heart hypertrophy and hypovolemia. © 2011 Elsevier B.V. All rights reserved.
dc.languageeng
dc.relationInternational Journal of Cardiology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject13-cis retinoic acid
dc.subjectAcne
dc.subjectCardiac remodeling
dc.subjectVitamin A
dc.subjectisotretinoin
dc.subjectacne vulgaris
dc.subjectadolescent
dc.subjectadult
dc.subjectcardiac remodeling
dc.subjectcardiovascular parameters
dc.subjectclinical article
dc.subjectDoppler echocardiography
dc.subjectheart disease
dc.subjectheart hypertrophy
dc.subjectheart index
dc.subjectheart left atrium diameter
dc.subjectheart left atrium volume
dc.subjectheart left ventricle diastolic diameter
dc.subjectheart left ventricle mass
dc.subjectheart left ventricle mass index
dc.subjectheart left ventricle systolic function
dc.subjectheart posterior wall diastolic thickness
dc.subjectheart relative wall relative thickness
dc.subjectheart right atrium
dc.subjectheart right atrium diameter
dc.subjectheart ventricle septum diastolic thickness
dc.subjecthuman
dc.subjecthypovolemia
dc.subjectmale
dc.subjectpriority journal
dc.titleCardiac remodeling induced by 13-cis retinoic acid treatment in acne patients
dc.typeOtro


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