Evaluation of the bone healing process utilizing platelet-rich plasma activated by thrombin and calcium chloride: A histologic study in rabbit calvaria

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorBetoni-Junior, Walter
dc.creatorDechichi, Paula
dc.creatorEsteves, Jônatas Caldeira
dc.creatorZanetta-Barbosa, Darceny
dc.creatorMagalhães, Aparecido Eurípedes Onório
dc.date2014-05-27T11:28:21Z
dc.date2016-10-25T18:43:29Z
dc.date2014-05-27T11:28:21Z
dc.date2016-10-25T18:43:29Z
dc.date2013-02-01
dc.date.accessioned2017-04-06T02:12:28Z
dc.date.available2017-04-06T02:12:28Z
dc.identifierJournal of Oral Implantology, v. 39, n. 1, p. 14-21, 2013.
dc.identifier0160-6972
dc.identifier1548-1336
dc.identifierhttp://hdl.handle.net/11449/74534
dc.identifierhttp://acervodigital.unesp.br/handle/11449/74534
dc.identifier10.1563/AAID-JOI-D-10-00043
dc.identifierWOS:000315556300003
dc.identifier2-s2.0-84875510234
dc.identifierhttp://dx.doi.org/10.1563/AAID-JOI-D-10-00043
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/895299
dc.descriptionTo evaluate the bone healing of defects filled with particulate bone graft in combination with platelet-rich plasma (PRP), added with a mixture of calcium chloride and thrombin or just calcium chloride. Two 5-mm bone defects were created in the calvaria of 24 rabbits. Each defect was filled with particulate bone graft and PRP. In one defect the PRP was activated by a mixture of calcium chloride and thrombin; in the other, PRP was activated by calcium chloride only. The animals were euthanized 1, 2, 4, and 8 weeks after the surgeries, and the calvaria was submitted to histologic processing for histomorphometric analysis. The qualitative analysis has shown that both defects presented the same histologic characteristics so that a better organized, more mature, and well-vascularized bone tissue was noticed in the eighth week. A good bone repair was achieved using either the mixture of calcium chloride and thrombin or the calcium chloride alone as a restarting agent of the coagulation process.
dc.languageeng
dc.relationJournal of Oral Implantology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBone graft
dc.subjectDental implants
dc.subjectGrowth factors
dc.subjectPlatelet-rich plasma
dc.subjectcalcium chloride
dc.subjectthrombin
dc.subjectanimal
dc.subjectblood clotting
dc.subjectbone regeneration
dc.subjectdrug effect
dc.subjectevaluation
dc.subjectrabbit
dc.subjectskull
dc.subjectthrombocyte rich plasma
dc.subjectAnimals
dc.subjectBlood Coagulation
dc.subjectBone Regeneration
dc.subjectCalcium Chloride
dc.subjectPlatelet-Rich Plasma
dc.subjectRabbits
dc.subjectSkull
dc.subjectThrombin
dc.titleEvaluation of the bone healing process utilizing platelet-rich plasma activated by thrombin and calcium chloride: A histologic study in rabbit calvaria
dc.typeOtro


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