Arterial hypertension perpetuates alveolar bone loss

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorVanderlei, Janine Montenegro Toscano Moura de Medeiros
dc.creatorMessora, Michel Reis
dc.creatorFernandes, Patrícia Garani
dc.creatorNovaes Jr., Arthur B.
dc.creatorPalioto, Daniela Bazan
dc.creatorGrisi, Marcio Fernando de Moraes
dc.creatorSouza, Sergio Luis Scombatti De
dc.creatorGerlach, Raquel Fernanda
dc.creatorSilva, Cristina Antoniali
dc.creatorTaba Jr., Mario
dc.date2014-05-27T11:28:01Z
dc.date2016-10-25T18:41:50Z
dc.date2014-05-27T11:28:01Z
dc.date2016-10-25T18:41:50Z
dc.date2013-01-07
dc.date.accessioned2017-04-06T02:09:03Z
dc.date.available2017-04-06T02:09:03Z
dc.identifierClinical and Experimental Hypertension, v. 35, n. 1, p. 1-5, 2013.
dc.identifier1064-1963
dc.identifier1525-6006
dc.identifierhttp://hdl.handle.net/11449/74353
dc.identifierhttp://acervodigital.unesp.br/handle/11449/74353
dc.identifier10.3109/10641963.2012.683969
dc.identifierWOS:000312869700001
dc.identifier2-s2.0-84871755751
dc.identifierhttp://dx.doi.org/10.3109/10641963.2012.683969
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/895120
dc.descriptionFew studies have focused on the impact of hypertension on the progression of periodontitis (PD). The purpose of this study was to evaluate whether hypertension affects PD by enhancing bone loss even after the stimulus for PD induction is removed. Ligature-induced PD was created on the first mandibular molars of spontaneously hypertensive rats (SHR) and normotensive rats (Wistar Kyoto-WKY). The animals were assigned to non-ligated controls (C) and PD groups: WKY-C, WKY-PD, SHR-C, and SHR-PD. After 10 days, five animals of each group were killed and the ligatures of the other animals were removed. On the 21st day (11 days without PD induced), the remaining animals were killed. The jaws were defleshed and the amount of bone loss was measured. After 10 days, the PD groups showed more bone loss than its controls (P < .05); SHR-PD = 0.72 ± 0.05 mm, SHR-C = 0.39 ± 0.04 mm, WKY-PD = 0.75 ± 0.04 mm, and WKY-C = 0.56 ± 0.04 mm. The cumulative bone loss on day 21 (0.94 ± 0.13 mm) was significantly worse than on day 10 only in SHR-PD group (P < .05). The final bone loss differences between PD and C groups accounted for 102% (SHR) and 26% (WKY) increase in comparison with the initial control levels. Hypertension is associated with progressive alveolar bone loss even when the stimulus for PD induction is removed and it may be speculated that host condition perpetuates alveolar bone loss. © 2013 Informa Healthcare USA, Inc.
dc.languageeng
dc.relationClinical and Experimental Hypertension
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAlveolar bone loss
dc.subjectAnimal model
dc.subjectHypertension
dc.subjectPeriodontitis
dc.subjectSHR
dc.subjectalveolar bone loss
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectbone metabolism
dc.subjectcontrolled study
dc.subjectdisease association
dc.subjecthypertension
dc.subjectjaw
dc.subjectmale
dc.subjectmandible
dc.subjectmolar tooth
dc.subjectmorphometrics
dc.subjectnonhuman
dc.subjectosteolysis
dc.subjectperiodontitis
dc.subjectrat
dc.subjectAlveolar Bone Loss
dc.subjectAnimals
dc.subjectDisease Models, Animal
dc.subjectDisease Progression
dc.subjectLigation
dc.subjectMale
dc.subjectRats
dc.subjectRats, Inbred SHR
dc.subjectRats, Inbred WKY
dc.titleArterial hypertension perpetuates alveolar bone loss
dc.typeOtro


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