Blends of cross-linked high amylose starch/pectin loaded with diclofenac

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorSoares, Grazielle Arantes
dc.creatorCastro, Ana Doris de
dc.creatorCury, Beatriz S.F.
dc.creatorEvangelista, Raul Cesar
dc.date2014-05-27T11:27:33Z
dc.date2016-10-25T18:41:45Z
dc.date2014-05-27T11:27:33Z
dc.date2016-10-25T18:41:45Z
dc.date2013-01-02
dc.date.accessioned2017-04-06T02:08:46Z
dc.date.available2017-04-06T02:08:46Z
dc.identifierCarbohydrate Polymers, v. 91, n. 1, p. 135-142, 2013.
dc.identifier0144-8617
dc.identifierhttp://hdl.handle.net/11449/74340
dc.identifierhttp://acervodigital.unesp.br/handle/11449/74340
dc.identifier10.1016/j.carbpol.2012.08.014
dc.identifierWOS:000310253800017
dc.identifier2-s2.0-84865459434.pdf
dc.identifier2-s2.0-84865459434
dc.identifierhttp://dx.doi.org/10.1016/j.carbpol.2012.08.014
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/895108
dc.descriptionPolymers blends represent an important approach to obtain materials with modulated properties to reach different and desired properties in designing drug delivery systems in order to fulfill therapeutic needs. The aim of this work was to evaluate the influence of drug loading and polymer ratio on the physicochemical properties of microparticles of cross-linked high amylose starch-pectin blends loaded with diclofenac for further application in controlled drug delivery systems. Thermal analysis and X-ray diffractograms evidenced the occurrence of drug-polymer interactions and the former pointed also to an increase in thermal stability due to drug loading. The rheological properties demonstrated that drug loading resulted in formation of weaker gels while the increase of pectin ratio contributes to origin stronger structures. © 2012 Elsevier Ltd.
dc.languageeng
dc.relationCarbohydrate Polymers
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHigh amylose starch
dc.subjectPectin
dc.subjectPolymer blends
dc.subjectRheology
dc.subjectThermal analysis
dc.subjectX-ray diffraction
dc.subjectControlled drug delivery systems
dc.subjectDiclofenac
dc.subjectDrug delivery system
dc.subjectDrug loading
dc.subjectDrug-polymer interaction
dc.subjectHigh amylose
dc.subjectMicro-particles
dc.subjectPhysicochemical property
dc.subjectRheological property
dc.subjectX-ray diffractograms
dc.subjectControlled drug delivery
dc.subjectCrosslinking
dc.subjectFunctional polymers
dc.subjectMaterials properties
dc.subjectStarch
dc.subjectThermoanalysis
dc.subjectX ray diffraction
dc.subjectLoading
dc.subjectamylose
dc.subjectdiclofenac
dc.subjectdrug carrier
dc.subjectmicrosphere
dc.subjectpectin
dc.subjectchemistry
dc.subjectflow kinetics
dc.subjectparticle size
dc.subjecttemperature
dc.subjectAmylose
dc.subjectDrug Carriers
dc.subjectMicrospheres
dc.subjectParticle Size
dc.subjectPectins
dc.subjectTemperature
dc.titleBlends of cross-linked high amylose starch/pectin loaded with diclofenac
dc.typeOtro


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