Synbiotic meal decreases uremic toxins in hemodialysis individuals: A placebo-controlled trial

dc.creatorLopes, Rita de Cássia Stampini Oliveira
dc.creatorTheodoro, Jaqueline Maciel Vieira
dc.creatorSilva, Bárbara Pereira da
dc.creatorQueiroz, Valéria Aparecida Vieira
dc.creatorMoreira, Maria Eliza de Castro
dc.creatorMantovani, Hilário Cuquetto
dc.creatorHermsdorff, Helen Hermana
dc.creatorMartino, Hércia Stampini Duarte
dc.date2019-03-13T12:05:26Z
dc.date2019-03-13T12:05:26Z
dc.date2019-02
dc.date.accessioned2023-09-27T20:55:44Z
dc.date.available2023-09-27T20:55:44Z
dc.identifier0963-9969
dc.identifierhttps://doi.org/10.1016/j.foodres.2018.08.024
dc.identifierhttp://www.locus.ufv.br/handle/123456789/23905
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8951054
dc.descriptionGeneration of uremic toxins p-cresylsulfate (p-CS), indoxyl sulfate (IS) and indole 3-acetic acid (IAA) in hemodialysis (HD) individuals may be associated with the gut flora and recognized markers of disease progression. This study investigated the effect of synbiotic meal on uremic toxins in HD individuals. We conducted randomized singleblind and placebo-controlled intervention study with 58 HD subjects (20F/38M, 63.1 ± 10.9-old) who were randomly allocated in synbiotic group (SG, 40 g of extruded sorghum plus 100 mL of unfermented probiotic milk) or control group (CG, 40 g of extruded corn plus 100 mL of pasteurized milk), during 7-wk Metabolic markers and uremic toxins, fecal concentration of short chain fatty acid and pH value was determined. The SG group had decreased serum p-CS and IS, as well as decreased urea concentration (p < .05) compared to CG. SG showed higher fecal butyric acid and lower pH compared to baseline and SC (p < .05). In addition, serum p-CS and fecal pH were positively correlated to urea concentration in SG participants at the endpoint. The consumption of the synbiotic meal during 7-wk reduced colonic pH, and reduced serum uremic (p-CS and IS) toxins and urea in HD subjects.
dc.formatpdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherFood Research International
dc.relationVolume 116, Pages 241-248, February 2019
dc.rightsElsevier B. V.
dc.subjectBifidobacterium longum
dc.subjectChronic kidney disease
dc.subjectIndoxyl sulfate
dc.subjectp-Cresylsulfate
dc.subjectSorghum bicolor L.
dc.subjectUrea
dc.titleSynbiotic meal decreases uremic toxins in hemodialysis individuals: A placebo-controlled trial
dc.typeArtigo


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