Chronic Ethanol Consumption Alters All-Trans-Retinoic Acid Concentration and Expression of Their Receptors on the Prostate: A Possible Link Between Alcoholism and Prostate Damage

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorFontanelli, Beatriz A.F.
dc.creatorChuffa, Luiz G.A.
dc.creatorTeixeira, Giovana R.
dc.creatorAmorim, João P.A.
dc.creatorMendes, Leonardo O.
dc.creatorPinheiro, Patricia F.F.
dc.creatorKurokawa, Cilmery Suemi
dc.creatorPereira, Sérgio
dc.creatorFávaro, Wagner J.
dc.creatorMartins, Otávio A.
dc.creatorMello Júnior, Wílson de
dc.creatorMartinez, Marcelo
dc.creatorRugolo Júnior, Antonio
dc.creatorMartinez, Francisco E.
dc.date2014-05-27T11:27:30Z
dc.date2016-10-25T18:41:04Z
dc.date2014-05-27T11:27:30Z
dc.date2016-10-25T18:41:04Z
dc.date2013-01-01
dc.date.accessioned2017-04-06T02:07:41Z
dc.date.available2017-04-06T02:07:41Z
dc.identifierAlcoholism: Clinical and Experimental Research, v. 37, n. 1, p. 49-56, 2013.
dc.identifier0145-6008
dc.identifier1530-0277
dc.identifierhttp://hdl.handle.net/11449/74226
dc.identifierhttp://acervodigital.unesp.br/handle/11449/74226
dc.identifier10.1111/j.1530-0277.2012.01866.x
dc.identifierWOS:000313115200008
dc.identifier2-s2.0-84872002927
dc.identifier0000-0003-0030-8198
dc.identifierhttp://dx.doi.org/10.1111/j.1530-0277.2012.01866.x
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/894998
dc.descriptionBackground: Ethanol (EtOH) alters the all-trans-retinoic acid (ATRA) levels in some tissues. Retinol and ATRA are essential for cell proliferation, differentiation, and maintenance of prostate homeostasis. It has been suggested that disturbances in retinol/ATRA concentration as well as in the expression of retinoic acid receptors (RARs) contribute to benign prostate hyperplasia and prostate cancer. This study aimed to evaluate whether EtOH consumption is able to alter retinol and ATRA levels in the plasma and prostate tissue as well as the expression of RARs, cell proliferation, and apoptosis index. Methods: All animals were divided into 4 groups (n = 10/group). UChA: rats fed 10% (v/v) EtOH ad libitum; UChACo: EtOH-naïve rats without access to EtOH; UChB: rats fed 10% (v/v) EtOH ad libitum; UChBCo: EtOH-naïve rats without access to EtOH. Animals were euthanized by decapitation after 60 days of EtOH consumption for high-performance liquid chromatography and light microscopy analysis. Results: EtOH reduced plasma retinol concentration in both UChA and UChB groups, while the retinol concentration was not significantly different in prostate tissue. Conversely, plasma and prostate ATRA levels increased in UChB group compared with controls, beyond the up-regulation of RARβ and -γ in dorsal prostate lobe. Additionally, no alteration was found in cell proliferation and apoptosis index involving dorsal and lateral prostate lobe. Conclusions: We conclude that EtOH alters the plasma retinol concentrations proportionally to the amount of EtOH consumed. Moreover, high EtOH consumption increases the concentration of ATRA in plasma/prostate tissue and especially induces the RARβ and RARγ in the dorsal prostate lobe. EtOH consumption and increased ATRA levels were not associated with cell proliferation and apoptosis in the prostate. © 2012 by the Research Society on Alcoholism.
dc.languageeng
dc.relationAlcoholism: Clinical and Experimental Research
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAll-Trans-Retinoic acid
dc.subjectEthanol
dc.subjectProstate
dc.subjectRetinoic acid receptor
dc.subjectRetinol
dc.subjectalcohol
dc.subjectretinoic acid
dc.subjectretinoic acid receptor
dc.subjectalcohol consumption
dc.subjectalcoholism
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectapoptosis
dc.subjectapoptosis index
dc.subjectblood analysis
dc.subjectcell proliferation
dc.subjectcellular parameters
dc.subjectcontrolled study
dc.subjectfood intake
dc.subjecthigh performance liquid chromatography
dc.subjectimmunohistochemistry
dc.subjectmale
dc.subjectmicroscopy
dc.subjectnick end labeling
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectprostate disease
dc.subjectprotein expression
dc.subjectrat
dc.subjectAlcohol Drinking
dc.subjectAnimals
dc.subjectApoptosis
dc.subjectCell Proliferation
dc.subjectCentral Nervous System Depressants
dc.subjectMale
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectReceptors, Retinoic Acid
dc.subjectTretinoin
dc.subjectAnimalia
dc.subjectRattus
dc.titleChronic Ethanol Consumption Alters All-Trans-Retinoic Acid Concentration and Expression of Their Receptors on the Prostate: A Possible Link Between Alcoholism and Prostate Damage
dc.typeOtro


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