Estrogen receptors alpha and beta in male and female gerbil prostates

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorRochel-Maia, Sabrina S.
dc.creatorSantos, Fernanda C.A.
dc.creatorAlonso-Magdalena, Paloma
dc.creatorGóes, Rejane Maira
dc.creatorVilamaior, Patricia S.L.
dc.creatorWarner, Margaret
dc.creatorGustafsson, Jan-Åke
dc.creatorTaboga, Sebastião Roberto
dc.date2014-05-27T11:27:29Z
dc.date2016-10-25T18:41:02Z
dc.date2014-05-27T11:27:29Z
dc.date2016-10-25T18:41:02Z
dc.date2013-01-01
dc.date.accessioned2017-04-06T02:07:33Z
dc.date.available2017-04-06T02:07:33Z
dc.identifierBiology of Reproduction, v. 88, n. 1, 2013.
dc.identifier0006-3363
dc.identifier1529-7268
dc.identifierhttp://hdl.handle.net/11449/74212
dc.identifierhttp://acervodigital.unesp.br/handle/11449/74212
dc.identifier10.1095/biolreprod.112.103614
dc.identifierWOS:000314357700006
dc.identifier2-s2.0-84877073435
dc.identifier0000-0002-0970-4288
dc.identifierhttp://dx.doi.org/10.1095/biolreprod.112.103614
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/894984
dc.descriptionThe Mongolian gerbil (Meriones unguiculatus, Gerbilinae: Muridae) is useful for prostate studies, because both males and females spontaneously develop prostatic disorders with age. Estrogens regulate prostate homeostasis via two estrogen receptors, ER alpha (ESR1) and ER beta (ESR2), but the cellular distribution and regulation of these receptors in the gerbil prostate has not been described. Both receptors were localized by immunohistochemistry in the ventral prostate of intact male and female gerbils, in males 7 and 21 days after castration, and in females treated with testosterone for 7 and 21 days. In male and female adult gerbils, ER alpha was detected mainly in prostatic stromal cells, whereas ER beta was present mostly in secretory and basal cells. More ER alpha-positive stromal cells were found in females than in males, as was a reduction toward the male value in females treated with testosterone. Castration did not alter ER alpha expression. Testosterone was necessary for maintenance of ER beta in the male prostate epithelium: ER beta expression declined markedly in prostates of males older than 1 yr, and castration of 4-mo-old males caused a reduction in ER beta to levels seen in 1-yr-old males. Because ER beta is an antiproliferative receptor, its loss with age may predispose the aging gerbil to proliferative diseases of the prostate. © 2013 by the Society for the Study of Reproduction, Inc.
dc.languageeng
dc.relationBiology of Reproduction
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCastration
dc.subjectEstradiol/estradiol receptor
dc.subjectEstrogen receptor
dc.subjectFemale
dc.subjectGerbil
dc.subjectProstate
dc.subjectSteroid hormones/steroid hormone receptors
dc.subjectStroma
dc.subjectTestosterone
dc.subjectestrogen receptor alpha
dc.subjectestrogen receptor beta
dc.subjecttestosterone
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectbasal cell
dc.subjectcastration
dc.subjectcellular distribution
dc.subjectcontrolled study
dc.subjectfemale
dc.subjectgerbil
dc.subjectimmunohistochemistry
dc.subjectmale
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectprostate ventral lobe
dc.subjectprotein expression
dc.subjectprotein localization
dc.subjectsecretory cell
dc.subjectstroma cell
dc.subjectAnimals
dc.subjectEstrogen Receptor alpha
dc.subjectEstrogen Receptor beta
dc.subjectEstrous Cycle
dc.subjectGene Expression Regulation
dc.subjectGerbillinae
dc.subjectMale
dc.subjectRandom Allocation
dc.titleEstrogen receptors alpha and beta in male and female gerbil prostates
dc.typeOtro


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