New label free CA125 detection based on gold nanostructured screen-printed electrode

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorRavalli, A.
dc.creatorPilon Dos Santos, G.
dc.creatorFerroni, M.
dc.creatorFaglia, G.
dc.creatorYamanaka, Hideko
dc.creatorMarrazza, G.
dc.date2014-05-27T11:27:29Z
dc.date2016-10-25T18:41:00Z
dc.date2014-05-27T11:27:29Z
dc.date2016-10-25T18:41:00Z
dc.date2013-01-01
dc.date.accessioned2017-04-06T02:07:24Z
dc.date.available2017-04-06T02:07:24Z
dc.identifierSensors and Actuators, B: Chemical, v. 179, p. 194-200.
dc.identifier0925-4005
dc.identifierhttp://hdl.handle.net/11449/74197
dc.identifierhttp://acervodigital.unesp.br/handle/11449/74197
dc.identifier10.1016/j.snb.2012.10.017
dc.identifierWOS:000316588100024
dc.identifier2-s2.0-84880921300
dc.identifierhttp://dx.doi.org/10.1016/j.snb.2012.10.017
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/894970
dc.descriptionThis paper describes the optimisation and the analytical performances of a label-free impedimetric immunosensor for the detection of tumour marker CA125 based on gold nanoparticles modified screen-printed graphite electrode. Experimental conditions of each step for the developed immunosensor were studied and optimised. The immunosensor response varied linearly (r2 = 0.996) with antigen concentration between 0 and 100 U/mL. The estimated detection limit was 6.7 U/mL. The electrochemical immunosensor allowed unambiguous identification of CA125, while no significant non-specific signal was detected in the case of all negative controls. The analytical usefulness of the impedimetric immunosensor was finally demonstrated analysing serum samples. © 2012 Elsevier B.V. All rights reserved.
dc.languageeng
dc.relationSensors and Actuators B: Chemical
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCA125
dc.subjectGold nanoparticles
dc.subjectImpedimetric immunosensor
dc.subjectScreen-printed electrode
dc.subjectTumour marker
dc.subjectAnalytical performance
dc.subjectDetection limits
dc.subjectElectrochemical immunosensors
dc.subjectExperimental conditions
dc.subjectGold Nanoparticles
dc.subjectImpedimetric immunosensors
dc.subjectScreen printed electrodes
dc.subjectGold
dc.subjectGraphite electrodes
dc.subjectMetal nanoparticles
dc.subjectTumors
dc.subjectImmunosensors
dc.titleNew label free CA125 detection based on gold nanostructured screen-printed electrode
dc.typeOtro


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