Caffeine reduces cadmium accumulation in the organism and enhances the levels of antioxidant protein expression in the epididymis

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorLacorte, Livia M.
dc.creatorSeiva, Fabio R.F.
dc.creatorRinaldi, Jaqueline C.
dc.creatorDelella, Flavia K.
dc.creatorMoroz, Andrei
dc.creatorSarobo, Carolina
dc.creatorGodinho, Antonio F.
dc.creatorFávaro, Wagner J.
dc.creatorFernandes, Ana A.H.
dc.creatorFelisbino, Sérgio L.
dc.date2014-05-27T11:27:29Z
dc.date2016-10-25T18:40:59Z
dc.date2014-05-27T11:27:29Z
dc.date2016-10-25T18:40:59Z
dc.date2013-01-01
dc.date.accessioned2017-04-06T02:07:22Z
dc.date.available2017-04-06T02:07:22Z
dc.identifierReproductive Toxicology, v. 35, n. 1, p. 137-143, 2013.
dc.identifier0890-6238
dc.identifier1873-1708
dc.identifierhttp://hdl.handle.net/11449/74194
dc.identifierhttp://acervodigital.unesp.br/handle/11449/74194
dc.identifier10.1016/j.reprotox.2012.10.009
dc.identifierWOS:000314003900017
dc.identifier2-s2.0-84871919665
dc.identifierhttp://dx.doi.org/10.1016/j.reprotox.2012.10.009
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/894967
dc.descriptionThe aim of this study was to investigate the effects of caffeine (20. mg/L) intake on cadmium (15. mg/L) accumulation in the rat blood, testes, epididymis and prostate as well as cadmium-induced changes to the antioxidant defense system of the epididymis. Caffeine reduced the cadmium concentration in all tissues analyzed. Meanwhile, cadmium reduced catalase activity and increased superoxide dismutase (SOD) activity in the epididymis. Caffeine increased SOD activity, catalase and glutathione tissue expression and sustains the cadmium's effect on catalase and GSP-Px activity. No differences in the expression of metallothionein and lipid peroxidation were observed among the different treatments in the epididymis. In conclusion, low doses of cadmium alter the antioxidant enzymatic profile of the epididymis, but not induced oxidative lipid damage. Caffeine intake reduces overall cadmium accumulation in the organism and enhances the levels of antioxidant protein expression in the epididymis, thus exerting a protective effect against this metal. © 2012 Elsevier Inc.
dc.languageeng
dc.relationReproductive Toxicology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAccumulation
dc.subjectCadmium
dc.subjectCaffeine
dc.subjectMale reproductive tract
dc.subjectOxidative stress
dc.subjectcadmium
dc.subjectcaffeine
dc.subjectcatalase
dc.subjectglutathione
dc.subjectglutathione peroxidase
dc.subjectmetallothionein
dc.subjectsuperoxide dismutase
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectantioxidant activity
dc.subjectbioaccumulation
dc.subjectconcentration response
dc.subjectcontrolled study
dc.subjectdiet supplementation
dc.subjectenzyme activity
dc.subjectepididymis
dc.subjectfluid intake
dc.subjectfood intake
dc.subjectlipid peroxidation
dc.subjectmale
dc.subjectnonhuman
dc.subjectoxidative stress
dc.subjectprotein expression
dc.subjectrat
dc.subjectreproductive toxicity
dc.subjectspermatozoon maturation
dc.subjecttissue distribution
dc.subjectupregulation
dc.subjectWestern blotting
dc.subjectAnimals
dc.subjectCatalase
dc.subjectEnvironmental Pollutants
dc.subjectEpididymis
dc.subjectGlutathione
dc.subjectGlutathione Peroxidase
dc.subjectLipid Peroxides
dc.subjectMale
dc.subjectOxidative Stress
dc.subjectProtective Agents
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSuperoxide Dismutase
dc.subjectTissue Distribution
dc.subjectRattus
dc.titleCaffeine reduces cadmium accumulation in the organism and enhances the levels of antioxidant protein expression in the epididymis
dc.typeOtro


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