dc.contributor | Universidade Estadual Paulista (UNESP) | |
dc.creator | Vieira, Daniela C.M. | |
dc.creator | Ricarte, Patrícia C. | |
dc.creator | Salgado, Hérida R.N. | |
dc.date | 2014-05-27T11:26:56Z | |
dc.date | 2016-10-25T18:37:53Z | |
dc.date | 2014-05-27T11:26:56Z | |
dc.date | 2016-10-25T18:37:53Z | |
dc.date | 2012-08-22 | |
dc.date.accessioned | 2017-04-06T02:00:23Z | |
dc.date.available | 2017-04-06T02:00:23Z | |
dc.identifier | Latin American Journal of Pharmacy, v. 31, n. 5, p. 746-750, 2012. | |
dc.identifier | 0326-2383 | |
dc.identifier | http://hdl.handle.net/11449/73510 | |
dc.identifier | http://acervodigital.unesp.br/handle/11449/73510 | |
dc.identifier | 2-s2.0-84865083152 | |
dc.identifier | http://www.latamjpharm.org/resumenes/31/5/LAJOP_31_5_2_2.pdf | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/894314 | |
dc.description | The validation of a microbiological assay, applying agar diffusion method for determination of the active of cefuroxime in power for injection, is described. Using a strain of Micrococcus luteus ATCC 9341 as the test organism, cefuroxime was measured in concentrations ranging from 30.0 to 120.0 μg/mL. The method validation showed that it is linear (r = 0.9999), precise (relative standard deviation = 0.37%) and accurate (it measured the added quantities). Microbiological assay is satisfactory for quantitation of cefuroxime in powder for injection and the validity of the proposed bioassay, which is a simple and a useful alternative methodology for cefuroxime determination in routine quality control. | |
dc.language | eng | |
dc.relation | Latin American Journal of Pharmacy | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Cefuroxime | |
dc.subject | Cephalosporins | |
dc.subject | Microbiological assay | |
dc.subject | Quality control | |
dc.subject | Validation | |
dc.subject | cefuroxime | |
dc.subject | agar diffusion | |
dc.subject | bacterial growth | |
dc.subject | bacterial strain | |
dc.subject | bacterium culture | |
dc.subject | calibration | |
dc.subject | correlation coefficient | |
dc.subject | drug determination | |
dc.subject | drug purity | |
dc.subject | drug structure | |
dc.subject | limit of detection | |
dc.subject | limit of quantitation | |
dc.subject | microbiology | |
dc.subject | Micrococcus luteus | |
dc.subject | quality control | |
dc.subject | validation study | |
dc.title | Validation of microbiological assay for determination of cefuroxime in injectable preparations | |
dc.type | Otro | |