The expression of aquaporins 1 and 9 in adult rat epididymis is perturbed by chronic exposure to ethanol

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorTeixeira, Giovana R.
dc.creatorChuffa, Luiz Gustavo A.
dc.creatorMartins, Otávio A.
dc.creatorKremer, Rafael
dc.creatorPinheiro, Patrícia Fernanda F.
dc.creatorMello Júnior, Wílson de
dc.creatorMartinez, Marcelo
dc.creatorMartinez, Francisco E.
dc.creatorDomeniconi, Raquel F.
dc.date2014-05-27T11:26:22Z
dc.date2016-10-25T18:36:34Z
dc.date2014-05-27T11:26:22Z
dc.date2016-10-25T18:36:34Z
dc.date2012-02-01
dc.date.accessioned2017-04-06T01:57:12Z
dc.date.available2017-04-06T01:57:12Z
dc.identifierTissue and Cell, v. 44, n. 1, p. 47-53, 2012.
dc.identifier0040-8166
dc.identifier1532-3072
dc.identifierhttp://hdl.handle.net/11449/73176
dc.identifierhttp://acervodigital.unesp.br/handle/11449/73176
dc.identifier10.1016/j.tice.2011.11.001
dc.identifier2-s2.0-84355166439
dc.identifierhttp://dx.doi.org/10.1016/j.tice.2011.11.001
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/893997
dc.descriptionAquaporins (AQPs), notably AQP-1 and AQP-9, may contribute to reabsorption of fluid and solute across the epididymis. Ethanol is related to be a toxicant affecting directly or indirectly the epididymis and the sperm motility. This study examined the expression of AQP-1 and AQP-9 in adult epididymis of the UChA and UChB 10% (v/v) ethanol-preferring rats, focusing the ethanol-induced hormonal disturbances upon the regulation of these AQPs. Chronic ethanol intake significantly decreased body weight, while UChA and UChB rats displayed a marked loss of epididymal weights. Both ethanol-consuming animals had a severe reduction of testosterone levels, whereas LH and 17β-estradiol were unchanged. Throughout the epididymis, a strong reaction to AQP-1 was observed in myoid and endothelial cells of the UChB ethanol-preferring rats, differently from a moderate intensity in the initial segment of the UChA rats. In addition, AQP-9 showed a strong immunoreaction in the apical membrane of principal cells at initial segment. In cauda epididymis, the level of AQP-9 was reduced along the microvillus projections in both UChA and UChB rats compared to controls. We conclude that chronic ethanol consumption modulates the androgen levels, thereby modifying the expression pattern of AQP-1 and 9 in the epididymis. © 2011 Elsevier Ltd.
dc.languageeng
dc.relationTissue and Cell
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAQP-1 and AQP-9
dc.subjectEpididymis
dc.subjectEthanol
dc.subjectUCh rats
dc.subjectalcohol
dc.subjectandrogen
dc.subjectaquaporin 1
dc.subjectaquaporin 9
dc.subjectestradiol
dc.subjectluteinizing hormone
dc.subjecttestosterone
dc.subjectalcohol consumption
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectapical membrane
dc.subjectbody weight
dc.subjectcontrolled study
dc.subjectendocrine disease
dc.subjectendothelium cell
dc.subjectepididymis disease
dc.subjectepididymis tail
dc.subjectimmunoreactivity
dc.subjectlong term exposure
dc.subjectmale
dc.subjectmicrovillus
dc.subjectnonhuman
dc.subjectorgan weight
dc.subjectprotein expression
dc.subjectrat
dc.subjectregulatory mechanism
dc.subjectAnimals
dc.subjectAquaporin 1
dc.subjectAquaporins
dc.subjectImmunohistochemistry
dc.subjectMale
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectTestosterone
dc.subjectAnimalia
dc.subjectMyoida
dc.subjectRattus
dc.titleThe expression of aquaporins 1 and 9 in adult rat epididymis is perturbed by chronic exposure to ethanol
dc.typeOtro


Este ítem pertenece a la siguiente institución