Frequency of ABO blood group system polymorphisms in Plasmodium falciparum malaria patients and blood donors from the Brazilian Amazon region.

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorCarvalho, D. B.
dc.creatorde Mattos, L. C.
dc.creatorSouza-Neiras, W. C.
dc.creatorBonini-Domingos, C. R.
dc.creatorCósimo, A. B.
dc.creatorStorti-Melo, L. M.
dc.creatorCassiano, G. C.
dc.creatorCouto, A. A.
dc.creatorCordeiro, A. J.
dc.creatorRossit, A. R.
dc.creatorMachado, R. L.
dc.date2014-05-27T11:25:22Z
dc.date2016-10-25T18:33:05Z
dc.date2014-05-27T11:25:22Z
dc.date2016-10-25T18:33:05Z
dc.date2010-12-01
dc.date.accessioned2017-04-06T01:47:56Z
dc.date.available2017-04-06T01:47:56Z
dc.identifierGenetics and molecular research : GMR, v. 9, n. 3, p. 1443-1449, 2010.
dc.identifier1676-5680
dc.identifierhttp://hdl.handle.net/11449/72107
dc.identifierhttp://acervodigital.unesp.br/handle/11449/72107
dc.identifier10.4238/vol9-3gmr803
dc.identifier2-s2.0-84855452304.pdf
dc.identifier2-s2.0-84855452304
dc.identifierhttp://dx.doi.org/10.4238/vol9-3gmr803
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/893010
dc.descriptionWe investigated the ABO genotypes and heterogeneity of the O alleles in Plasmodium falciparum-infected and non-infected individuals from the Brazilian Amazon region. Sample collection took place from May 2003 to August 2005, from P. falciparum malaria patients from four endemic regions of the Brazilian Amazon. The control group consisted of donors from four blood banks in the same areas. DNA was extracted using the Easy-DNA(TM) extraction kit. ABO genotyping was performed using PCR/RFLP. There was a high frequency of ABO*O01O01. ABO*AO01 was the second most frequent genotype, and the third most frequent genotype was ABO*BO01. There were low frequencies of the ABO*O01O02, ABO*AA, ABO*AB, ABO*BB, and ABO*O02O02 genotypes. We analyzed the alleles of the O phenotype; the O(1variant) allele was the most frequent, both in malaria and non-malaria groups; consequently, the homozygous genotype O(1)(v)O(1)(v) was the most frequently observed. There was no evidence of the homozygous O(2) allele. Significant differences were not detected in the frequency of individuals with the various alleles in the comparison of the malaria patients and the general population (blood donors).
dc.languageeng
dc.relationGenetics and molecular research : GMR
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectadolescent
dc.subjectadult
dc.subjectaged
dc.subjectblood donor
dc.subjectblood group ABO system
dc.subjectBrazil
dc.subjectfemale
dc.subjectgenetic polymorphism
dc.subjectgenetics
dc.subjecthuman
dc.subjectmalaria falciparum
dc.subjectmale
dc.subjectmiddle aged
dc.subjectpolymerase chain reaction
dc.subjectrestriction fragment length polymorphism
dc.subjectABO Blood-Group System
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectBlood Donors
dc.subjectFemale
dc.subjectHumans
dc.subjectMalaria, Falciparum
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPolymerase Chain Reaction
dc.subjectPolymorphism, Genetic
dc.subjectPolymorphism, Restriction Fragment Length
dc.subjectYoung Adult
dc.titleFrequency of ABO blood group system polymorphisms in Plasmodium falciparum malaria patients and blood donors from the Brazilian Amazon region.
dc.typeOtro


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