Profile of cardiovascular risk factors and mortality in patients with symptomatic peripheral arterial disease

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorZanati, Silméia Garcia
dc.creatorMouraria, Guilherme Grisi
dc.creatorMatsubara, Luiz Shiguero
dc.creatorGiannini, Mariângela
dc.creatorMatsubara, Beatriz Bojikian
dc.date2014-05-27T11:23:56Z
dc.date2016-10-25T18:27:11Z
dc.date2014-05-27T11:23:56Z
dc.date2016-10-25T18:27:11Z
dc.date2009-07-22
dc.date.accessioned2017-04-06T01:36:41Z
dc.date.available2017-04-06T01:36:41Z
dc.identifierClinics, v. 64, n. 4, p. 323-326, 2009.
dc.identifier1807-5932
dc.identifierhttp://hdl.handle.net/11449/71094
dc.identifierhttp://acervodigital.unesp.br/handle/11449/71094
dc.identifier10.1590/S1807-59322009000400010
dc.identifierS1807-59322009000400010
dc.identifier2-s2.0-67650607185.pdf
dc.identifier2-s2.0-67650607185
dc.identifierhttp://dx.doi.org/10.1590/S1807-59322009000400010
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/892122
dc.descriptionIntroduction: The present study examines cardiovascular risk factor profiles and 24-month mortality in patients with symptomatic peripheral arterial disease. Design Study: Prospective observational study including 75 consecutive patients with PAD (67 ± 9.7 years of age; 52 men and 23 women) hospitalized for planned peripheral vascular reconstruction. Doppler echocardiograms were performed before surgery in 54 cases. Univariate analyses were performed using Student's t-test or Fisher's exact test. Survival analysis at 24-month follow-up was performed using the Cox regression model and Kaplan-Meier method including age and chronic use of aspirin as covariates. Survival curves were compared using the log-rank test. Results: Hypertension and smoking were the most frequent risk factors (52 cases and 51 cases, respectively), followed by diabetes (32 cases). Undertreated dyslipidemia was found in 26 cases. Fasting glycine levels (131 ± 69.1 mg/dl) were elevated in 29 cases. Myocardial hypertrophy was found in 18 out of 54 patients. Thirty-four patients had been treated with aspirin. Overall mortality over 24 months was 24% and was associated with age (HR: 0.064; CI95: 0.014-0.115; p=0.013) and lack of use of aspirin, as no deaths occurred among those using this drug (p<0.001). No association was found between cardiovascular death (11 cases) and the other risk factors. Conclusion: There is a high prevalence of uncontrolled (treated or untreated) cardiovascular risk factors in patients undergoing planned peripheral vascular reconstruction, and chronic use of aspirin is associated with reduced all-cause mortality in these patients.
dc.languageeng
dc.relationClinics
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAspirin
dc.subjectCardiovascular risk
dc.subjectElderly
dc.subjectSmoking
dc.subjectVascular surgery
dc.subjectacetylsalicylic acid
dc.subjectantithrombocytic agent
dc.subjectaged
dc.subjectBrazil
dc.subjectcoronary artery disease
dc.subjectfemale
dc.subjecthuman
dc.subjecthypertension
dc.subjectKaplan Meier method
dc.subjectmale
dc.subjectmortality
dc.subjectperipheral vascular disease
dc.subjectprospective study
dc.subjectrisk factor
dc.subjectsmoking
dc.subjectsurvival
dc.subjectAged
dc.subjectCoronary Artery Disease
dc.subjectFemale
dc.subjectHumans
dc.subjectHypertension
dc.subjectKaplan-Meiers Estimate
dc.subjectMale
dc.subjectPeripheral Vascular Diseases
dc.subjectPlatelet Aggregation Inhibitors
dc.subjectProspective Studies
dc.subjectRisk Factors
dc.subjectSurvival Analysis
dc.titleProfile of cardiovascular risk factors and mortality in patients with symptomatic peripheral arterial disease
dc.typeOtro


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