Metabolic syndrome signs in Wistar rats submitted to different high-fructose ingestion protocols

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorde Moura, Rodrigo Ferreira
dc.creatorRibeiro, Carla
dc.creatorde Oliveira, Juliana Aparecida
dc.creatorStevanato, Eliane
dc.creatorde Mello, Maria Alice Rostom
dc.date2014-05-27T11:23:56Z
dc.date2016-10-25T18:27:09Z
dc.date2014-05-27T11:23:56Z
dc.date2016-10-25T18:27:09Z
dc.date2009-07-03
dc.date.accessioned2017-04-06T01:36:37Z
dc.date.available2017-04-06T01:36:37Z
dc.identifierBritish Journal of Nutrition, v. 101, n. 8, p. 1178-1184, 2009.
dc.identifier0007-1145
dc.identifier1475-2662
dc.identifierhttp://hdl.handle.net/11449/71087
dc.identifierhttp://acervodigital.unesp.br/handle/11449/71087
dc.identifier10.1017/S0007114508066774
dc.identifier2-s2.0-67649429383.pdf
dc.identifier2-s2.0-67649429383
dc.identifierhttp://dx.doi.org/10.1017/S0007114508066774
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/892115
dc.descriptionIn search of an adequate model for the human metabolic syndrome, the metabolic characteristics of Wistar rats were analysed after being submitted to different protocols of high fructose ingestion. First, two adult rat groups (aged 90 d) were studied: a control group (C1; n 6) received regular rodent chow (Labina, Purina) and a fructose group (F1; n 6) was fed on regular rodent chow. Fructose was administered as a 10 % solution in drinking water. Second, two adult rat groups (aged 90 d) were evaluated: a control group (C2; n 6) was fed on a balanced diet (AIN-93G) and a fructose group (F2; n 6) was fed on a purified 60 % fructose diet. Finally, two young rat groups (aged 28 d) were analysed: a control group (C3; n 6) was fed on the AIN-93G diet and a fructose group (F3; n 6) was fed on a 60 % fructose diet. After 4-8 weeks, the animals were evaluated. Glucose tolerance, peripheral insulin sensitivity, blood lipid profile and body fat were analysed. In the fructose groups F2 and F3 glucose tolerance and insulin sensitivity were lower, while triacylglycerolaemia was higher than the respective controls C2 and C3 (P < 0.05). Blood total cholesterol, HDL and LDL as well as body fat showed change only in the second protocol. In conclusion, high fructose intake is more effective at producing the signs of the metabolic syndrome in adult than in young Wistar rats. Additionally, diet seems to be a more effective way of fructose administration than drinking water.
dc.languageeng
dc.relationBritish Journal of Nutrition
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBody fat
dc.subjectFructose
dc.subjectInsulin sensitivity
dc.subjectMetabolic syndrome
dc.subjectcholesterol
dc.subjectdrinking water
dc.subjectfructose
dc.subjecthigh density lipoprotein cholesterol
dc.subjectlipid
dc.subjectlow density lipoprotein cholesterol
dc.subjecttriacylglycerol
dc.subjectage distribution
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectbody fat
dc.subjectcarbohydrate intake
dc.subjectcholesterol blood level
dc.subjectcontrolled study
dc.subjectexperimental rat
dc.subjectfood analysis
dc.subjectfood composition
dc.subjectfructose metabolism
dc.subjectglucose tolerance
dc.subjecthypertriglyceridemia
dc.subjectinsulin sensitivity
dc.subjectlipid blood level
dc.subjectmale
dc.subjectmetabolic balance
dc.subjectmetabolic syndrome X
dc.subjectnonhuman
dc.subjectrat
dc.subjecttriacylglycerol blood level
dc.subjectWistar rat
dc.subjectAnimals
dc.subjectBlood Glucose
dc.subjectCholesterol
dc.subjectDisease Models, Animal
dc.subjectGlucose Tolerance Test
dc.subjectInsulin
dc.subjectInsulin Resistance
dc.subjectMale
dc.subjectMetabolic Syndrome X
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectWeight Gain
dc.subjectAnimalia
dc.subjectRattus
dc.subjectRattus norvegicus
dc.subjectRodentia
dc.titleMetabolic syndrome signs in Wistar rats submitted to different high-fructose ingestion protocols
dc.typeOtro


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