Efectos de la administración de betabloqueante en la remodelación ventricular inducida por el tabaquismo en ratas

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorDuarte, Daniella R.
dc.creatorOliveira, Lucienne C.
dc.creatorMinicucci, Marcos Ferreira
dc.creatorGaiolla, Paula Schmidt Azevedo
dc.creatorMatsubara, Beatriz Bojikian
dc.creatorMatsubara, Luiz Shiguero
dc.creatorCampana, Álvaro O.
dc.creatorPaiva, Sergio Alberto Rupp de
dc.creatorZornoff, Leonardo Antonio Mamede
dc.date2014-05-27T11:23:54Z
dc.date2016-10-25T18:27:02Z
dc.date2014-05-27T11:23:54Z
dc.date2016-10-25T18:27:02Z
dc.date2009-06-01
dc.date.accessioned2017-04-06T01:36:08Z
dc.date.available2017-04-06T01:36:08Z
dc.identifierArquivos Brasileiros de Cardiologia, v. 92, n. 6, 2009.
dc.identifier0066-782X
dc.identifier1678-4170
dc.identifierhttp://hdl.handle.net/11449/71015
dc.identifierhttp://acervodigital.unesp.br/handle/11449/71015
dc.identifier10.1590/S0066-782X2009000600011
dc.identifierS0066-782X2009000600011
dc.identifier2-s2.0-68049098946.pdf
dc.identifier2-s2.0-68049098946
dc.identifierhttp://dx.doi.org/10.1590/S0066-782X2009000600011
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/892062
dc.descriptionBackground: The role of the adrenergic system on ventricular remodeling induced by cigarette smoking is unknown. Objective: To investigate the influence of propranolol on ventricular remodeling induced by exposure to tobacco smoke. Methods: Rats were divided into three groups: 1) C, n=10 - control group; 2) F, n=10 - animals exposed to tobacco smoke; 3) BB, n=10 - animals receiving propranolol and exposed to tobacco smoke (40 mg/kg/day). After 2 months, the animals underwent echocardiographic and morphometric analyses. One-way ANOVA (mean ± standard deviation) or the Kruskal-Wallis test (median and interquartile interval) was used. Results: Group BB showed a lower heart rate than group F (C = 358 ± 74 bpm, F = 374 ± 53 bpm, BB = 297± 30; P = 0.02). Group F showed greater end-diastolic diameters (C = 18.6 ± 3.4 mm/kg, F = 22.8 ± 1.8 mm/kg, BB = 21.7 ± 1.8 mm/kg; P = 0.003) and left ventricular (LV) end-systolic diameters (C = 8.6 ± 2.1 mm/kg, F = 11.3 ± 1.3 mm/kg, BB = 9.9 ± 1.2 mm/kg; P = 0.004), adjusted for body weight (BW) and a tendency towards a lower ejection fraction (C = 0.90 ± 0.03, F = 0.87 ± 0.03, BB =0.90 ± 0.02; P = 0.07) than group C. Group BB showed a tendency towards a lower LV/BW ratio than group F (C = 1.94 (1.87 - 1.97), F = 2.03 (1.9-2.1) mg/g, BB = 1.89 (1.86-1.94); P = 0.09). Conclusion: Administration of propranolol attenuated some of the variables of ventricular remodeling induced by the exposure to tobacco smoke in rats.
dc.languagepor
dc.languagespa
dc.languageeng
dc.relationArquivos Brasileiros de Cardiologia
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAdrenergic beta-antagonists/administration & dosage
dc.subjectRats
dc.subjectSmoking
dc.subjectVentricular remodeling
dc.subjectpropranolol
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectbody weight
dc.subjectcigarette smoking
dc.subjectcontrolled study
dc.subjectechocardiography
dc.subjectheart ejection fraction
dc.subjectheart rate
dc.subjectheart ventricle remodeling
dc.subjectmale
dc.subjectmorphometrics
dc.subjectnonhuman
dc.subjectrat
dc.subjectAdrenergic beta-Antagonists
dc.subjectAnimals
dc.subjectInhalation Exposure
dc.subjectMale
dc.subjectModels, Animal
dc.subjectPropranolol
dc.subjectRats, Wistar
dc.subjectTobacco Smoke Pollution
dc.subjectVentricular Dysfunction, Left
dc.subjectVentricular Remodeling
dc.titleEfectos de la administración de betabloqueante en la remodelación ventricular inducida por el tabaquismo en ratas
dc.typeOtro


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