Flavonoids with gastroprotective activity

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorDe Lira Mota, Kelly Samara
dc.creatorDias, Guilherme Eduardo Nunes
dc.creatorPinto, Meri Emili Ferreira
dc.creatorLuiz-Ferreira, Ânderson
dc.creatorSouza-Brito, Alba Regina Monteiro
dc.creatorHiruma-Lima, Clélia Akiko
dc.creatorBarbosa-Filho, José Maria
dc.creatorBatista, Leônia Maria
dc.date2014-05-27T11:23:52Z
dc.date2016-10-25T18:26:53Z
dc.date2014-05-27T11:23:52Z
dc.date2016-10-25T18:26:53Z
dc.date2009-03-01
dc.date.accessioned2017-04-06T01:35:36Z
dc.date.available2017-04-06T01:35:36Z
dc.identifierMolecules, v. 14, n. 3, p. 979-1012, 2009.
dc.identifier1420-3049
dc.identifierhttp://hdl.handle.net/11449/70947
dc.identifierhttp://acervodigital.unesp.br/handle/11449/70947
dc.identifier10.3390/molecules14030979
dc.identifier2-s2.0-63449104070.pdf
dc.identifier2-s2.0-63449104070
dc.identifier0000-0002-8645-3777
dc.identifierhttp://dx.doi.org/10.3390/molecules14030979
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/892001
dc.descriptionPeptic ulcers are a common disorder of the entire gastrointestinal tract that occurs mainly in the stomach and the proximal duodenum. This disease is multifactorial and its treatment faces great difficulties due to the limited effectiveness and severe side effects of the currently available drugs. The use of natural products for the prevention and treatment of different pathologies is continuously expanding throughout the world. This is particularly true with regards to flavonoids, which represent a highly diverse class of secondary metabolites with potentially beneficial human health effects that is widely distributed in the plant kingdom and currently consumed in large amounts in the diet. They display several pharmacological properties in the gastroprotective area, acting as anti-secretory, cytoprotective and antioxidant agents. Besides their action as gastroprotectives, flavonoids also act in healing of gastric ulcers and additionally these polyphenolic compounds can be new alternatives for suppression or modulation of peptic ulcers associated with H. pylori. In this review, we have summarized the literature on ninety-five flavonoids with varying degrees of antiulcerogenic activity, confirming that flavonoids have a therapeutic potential for the more effective treatment of peptic ulcers.
dc.languageeng
dc.relationMolecules
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectFlavonoids
dc.subjectGastroprotective activity
dc.subjectNatural products.
dc.subjectPeptic ulcers
dc.subjectflavonoid
dc.subjectphenol derivative
dc.subjectpolyphenols
dc.subjectprotective agent
dc.subjecthuman
dc.subjectpeptic ulcer
dc.subjectreview
dc.subjectHumans
dc.subjectPeptic Ulcer
dc.subjectPhenols
dc.subjectProtective Agents
dc.titleFlavonoids with gastroprotective activity
dc.typeOtro


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