Research of new mixed-chelate copper complexes with quinoxaline N 1,N 4,-dioxide derivatives and alanine as ligands, potential antimycobacterial agents

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorBelén Tarallo, M.
dc.creatorCosta-Filho, A. J.
dc.creatorVieira, Ernanni D.
dc.creatorMonge, Antonio
dc.creatorLeite, Clarice Q.
dc.creatorPavan, Fernando Rogério
dc.creatorBorthagaray, Graciela
dc.creatorGambino, Dinorah
dc.creatorTorre, María H.
dc.date2014-05-27T11:23:51Z
dc.date2016-10-25T18:26:48Z
dc.date2014-05-27T11:23:51Z
dc.date2016-10-25T18:26:48Z
dc.date2009-01-01
dc.date.accessioned2017-04-06T01:35:17Z
dc.date.available2017-04-06T01:35:17Z
dc.identifierJournal of the Argentine Chemical Society, v. 97, n. 1, p. 80-89, 2009.
dc.identifier0365-0375
dc.identifierhttp://hdl.handle.net/11449/70908
dc.identifierhttp://acervodigital.unesp.br/handle/11449/70908
dc.identifier2-s2.0-79959608363
dc.identifierhttp://www.aqa.org.ar/pdf9701/9701art8.pdf
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/891965
dc.descriptionThree new mixed-chelate copper complexes with 3-aminoquinoxaline-2-carbonitrile N 1,N 4-dioxide derivatives and alanine as ligands were synthesized in solid state. The spectroscopic characterization (FTIR, EPR, UV-Vis) showed that copper coordinated through the amine and the N-oxide groups of the quinoxaline derivatives and the amine and carboxylate moieties from alanine forming a dimeric species. The tree complexes showed in vitro activity against M. tuberculosis H 37Rv (ATCC 27294) similar to that of ethambutol while they are inactive against E. coli and S. aureus.
dc.languageeng
dc.relationJournal of the Argentine Chemical Society
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAntimycobacterial agents
dc.subjectCopper complexes
dc.subjectQuinoxaline derivatives
dc.titleResearch of new mixed-chelate copper complexes with quinoxaline N 1,N 4,-dioxide derivatives and alanine as ligands, potential antimycobacterial agents
dc.typeOtro


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