Effects of atrazine on female Wistar rats: Morphological alterations in ovarian follicles and immunocytochemical labeling of 90 kDa heat shock protein

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorJuliani, C. C.
dc.creatorSilva-Zacarin, E. C M
dc.creatorSantos, D. C.
dc.creatorBoer, P. A.
dc.date2014-05-27T11:23:35Z
dc.date2016-10-25T18:25:39Z
dc.date2014-05-27T11:23:35Z
dc.date2016-10-25T18:25:39Z
dc.date2008-07-01
dc.date.accessioned2017-04-06T01:31:15Z
dc.date.available2017-04-06T01:31:15Z
dc.identifierMicron, v. 39, n. 5, p. 607-616, 2008.
dc.identifier0968-4328
dc.identifierhttp://hdl.handle.net/11449/70448
dc.identifierhttp://acervodigital.unesp.br/handle/11449/70448
dc.identifier10.1016/j.micron.2007.04.006
dc.identifier2-s2.0-44949197583
dc.identifierhttp://dx.doi.org/10.1016/j.micron.2007.04.006
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/891548
dc.descriptionFertility in female mammals may be affected by a variety of endocrine disrupters present in the environment. Herbicide atrazine is an example of endocrine disrupter employed in agriculture, which disrupts estrous cyclicity in rats. Aiming to characterize morphologically the effect of low and sublethal doses of atrazine on the ovaries of Wistar rats, in an effort to determine the possible intrafollicular target site through which this herbicide acts adult females were submitted to both subacute and subchronic treatments. Additionally, immunocytochemical labeling of 90 kDa heat shock protein (HSP90) was performed in order to evaluate the role played by this protein in the ovary, under stressed conditions induced by herbicide exposure. The results indicated that atrazine induced impaired folliculogenesis, increased follicular atresia and HSP90 depletion in female rats submitted to subacute treatment, while the subchronic treatment with low dose of atrazine could compromise the reproductive capacity reflected by the presence of multioocytic follicle and stress-inducible HSP90. © 2007 Elsevier Ltd. All rights reserved.
dc.languageeng
dc.relationMicron
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCell death
dc.subjectChaperone
dc.subjectEnvironmental toxicology
dc.subjectFertility
dc.subjectFolliculogenesis
dc.subjectGranulosa cell
dc.subjectOocyte
dc.subjectAgricultural engineering
dc.subjectBiodiversity
dc.subjectEndocrinology
dc.subjectLabeling
dc.subjectMammals
dc.subjectPest control
dc.subjectPhotoacoustic effect
dc.subjectPigments
dc.subjectPlasmas
dc.subjectProteins
dc.subjectRats
dc.subjectWeed control
dc.subject(abiotic and biotic) stress
dc.subject(I ,J) conditions
dc.subjectadult females
dc.subjectAtrazine (ATR)
dc.subjectCyclicity
dc.subjectElsevier (CO)
dc.subjectEndocrine disrupters
dc.subjectFemale Wistar rats
dc.subjectHeat shock protein (Hsp)
dc.subjectHerbicide exposure
dc.subjectImmunocytochemical
dc.subjectIn order
dc.subjectlow dose
dc.subjectOvarian follicles
dc.subjectReproductive capacity
dc.subjectSubchronic
dc.subjectSublethal doses
dc.subjectWistar rats
dc.subjectHerbicides
dc.subjectatrazine
dc.subjectheat shock protein 90
dc.subjectherbicide
dc.subjectanimal
dc.subjectdrug effect
dc.subjectfemale
dc.subjectfertility
dc.subjectimmunohistochemistry
dc.subjectmetabolism
dc.subjectmethodology
dc.subjectovary
dc.subjectovary follicle
dc.subjectovary follicle atresia
dc.subjectphysiology
dc.subjectrat
dc.subjectultrastructure
dc.subjectWistar rat
dc.subjectAnimals
dc.subjectAtrazine
dc.subjectFemale
dc.subjectFollicular Atresia
dc.subjectHSP90 Heat-Shock Proteins
dc.subjectImmunohistochemistry
dc.subjectOvarian Follicle
dc.subjectOvary
dc.subjectRats, Wistar
dc.subjectMammalia
dc.subjectRattus
dc.subjectRattus norvegicus
dc.titleEffects of atrazine on female Wistar rats: Morphological alterations in ovarian follicles and immunocytochemical labeling of 90 kDa heat shock protein
dc.typeOtro


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