Antimycobacterial activity of some Brazilian indigenous medicinal drinks

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorOliveira, D. G.
dc.creatorPrince, K. A.
dc.creatorHiguchi, C. T.
dc.creatorSantos, A. C. B.
dc.creatorLopes, Lucia Maria Xavier
dc.creatorSimões, M. J. S.
dc.creatorLeite, Clarice Queico Fujimura
dc.date2014-05-27T11:22:43Z
dc.date2016-10-25T18:24:52Z
dc.date2014-05-27T11:22:43Z
dc.date2016-10-25T18:24:52Z
dc.date2007-12-01
dc.date.accessioned2017-04-06T01:28:39Z
dc.date.available2017-04-06T01:28:39Z
dc.identifierRevista de Ciencias Farmaceuticas Basica e Aplicada, v. 28, n. 2, p. 165-169, 2007.
dc.identifier1808-4532
dc.identifierhttp://hdl.handle.net/11449/70137
dc.identifierhttp://acervodigital.unesp.br/handle/11449/70137
dc.identifier2-s2.0-41349106999.pdf
dc.identifier2-s2.0-41349106999
dc.identifierhttp://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/view/321
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/891281
dc.descriptionTuberculosis (TB) is a very serious problem worldwide and the increasing number of multiple drugs resistant TB cases makes the search for new anti-TB drugs an urgent need. Indigenous knowledge about the use of native plants to treat illnesses has contributed to the discovery of new medicines. In this study, the antimycobacterial activity of seven medicinal drinks was assessed: Ananas sativus (hydroalcoholic fruit extract), Aristolochia triangularis (aqueous and hydroalcoholic leaf, root and stem extracts), Bromelia antiacantha (hydroalcoholic fruit extract), Stryphnodendron adstringens (hydroalcoholic bark extract), Tabebuia ovellanedae (hydroalcoholic bark extract), Vernonia polyanthes (hydroalcoholic root extract), all used by the Vanuíre indigenous community in the treatment of respiratory diseases. The activity was evaluated by using a time-to-kill assay, in which Mycobacterium tuberculosis H37Rv was cultured on Löwenstein-Jensen medium, after thirty minutes, one, three, six, twelve and twenty-four hours contact of the bacteria with each drink. Within half to one hour contact, the hydroalcoholic drinks of A. triangularis, S. adstringens, T. ovellanedae and V. polyanthes reduced the bacterial growth by 2 orders of magnitude in CFU/mL, and all bacterial growth was absent after three hours contact. In contrast, no mycobactericidal effect was detected in the aqueous extract of A. triangularis or in the hydroalcoholic beverages of A. sativus and B. antiacantha, even after twenty-four hours contact.
dc.languageeng
dc.relationRevista de Ciências Farmacêuticas Básica e Aplicada
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAristolochia triangularis
dc.subjectIndigenous drinks
dc.subjectStryphnodendron adstringens
dc.subjectTabebuia ovellanedae
dc.subjectTuberculosis
dc.subjectVernonia polyanthes
dc.subjectAnanas sativus extract
dc.subjectAristolochw triangularis extract
dc.subjectBromelia antiacantha extract
dc.subjectplant extract
dc.subjectStryphnodendron adstringens extract
dc.subjectTabebuia ovellanedae extract
dc.subjectunclassified drug
dc.subjectVernonia polyanthes extract
dc.subjectantimicrobial activity
dc.subjectaqueous solution
dc.subjectbacterial growth
dc.subjectbark
dc.subjectcolony forming unit
dc.subjectcontrolled study
dc.subjectfruit
dc.subjectlung tuberculosis
dc.subjectMycobacterium tuberculosis
dc.subjectnonhuman
dc.subjectplant leaf
dc.subjectplant root
dc.titleAntimycobacterial activity of some Brazilian indigenous medicinal drinks
dc.typeOtro


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