Biomolecular information, brain activity and cognitive functions

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorPereira Jr., Alfredo
dc.creatorFurlan, Fábio Augusto
dc.date2014-05-27T11:22:42Z
dc.date2016-10-25T18:24:49Z
dc.date2014-05-27T11:22:42Z
dc.date2016-10-25T18:24:49Z
dc.date2007-12-01
dc.date.accessioned2017-04-06T01:28:27Z
dc.date.available2017-04-06T01:28:27Z
dc.identifierAnnual Review of Biomedical Sciences, v. 9, p. 12-29.
dc.identifier1806-8774
dc.identifierhttp://hdl.handle.net/11449/70112
dc.identifierhttp://acervodigital.unesp.br/handle/11449/70112
dc.identifier10.5016/1806-8774.2007v9p12
dc.identifier2-s2.0-38149116113.pdf
dc.identifier2-s2.0-38149116113
dc.identifier0000-0002-5960-041X
dc.identifierhttp://dx.doi.org/10.5016/1806-8774.2007v9p12
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/891259
dc.descriptionMolecular neurobiology has provided an explanation of mechanisms supporting mental functions as learning, memory, emotion and consciousness. However, an explanatory gap remains between two levels of description: molecular mechanisms determining cellular and tissue functions, and cognitive functions. In this paper we review molecular and cellular mechanisms that determine brain activity, and then hypothetize about their relation with cognition and consciousness. The brain is conceived of as a dynamic system that exchanges information with the whole body and the environment. Three explanatory hypotheses are presented, stating that: a) brain tissue function is coordinated by macromolecules controlling ion movements, b) structured (amplitude, frequency and phase-modulated) local field potentials generated by organized ionic movement embody cognitive information patterns, and c) conscious episodes are constructed by a large-scale mechanism that uses oscillatory synchrony to integrate local field patterns. © by São Paulo State University.
dc.languageeng
dc.relationAnnual Review of Biomedical Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBiomolecular information
dc.subjectBrain function
dc.subjectCognition
dc.subjectLocal field potentials
dc.subjectMolecular neurobiology
dc.subjectdopamine
dc.subjectserotonin
dc.subjectAMPA receptor
dc.subjectangiotensin
dc.subjectbombesin
dc.subjectbradykinin
dc.subjectcalcium ion
dc.subjectchloride ion
dc.subjectcholecystokinin
dc.subjectcorticotropin
dc.subjectcorticotropin releasing factor
dc.subjectdelta sleep inducing peptide
dc.subjectdynorphin
dc.subjectendorphin
dc.subjectenkephalin
dc.subjectG protein coupled receptor
dc.subjectinsulin
dc.subjectmetabotropic receptor
dc.subjectn methyl dextro aspartic acid receptor
dc.subjectneuropeptide
dc.subjectneuropeptide Y
dc.subjectneurotensin
dc.subjectoxytocin
dc.subjectpotassium ion
dc.subjectprolactin
dc.subjectprotirelin
dc.subjectsodium ion
dc.subjectsubstance P
dc.subjectvasopressin
dc.subjectaction potential
dc.subjectcell cycle
dc.subjectcognition
dc.subjectconsciousness
dc.subjectelectricity
dc.subjectelectroencephalogram
dc.subjectexcitatory postsynaptic potential
dc.subjecthuman
dc.subjecthyperpolarization
dc.subjectinhibitory postsynaptic potential
dc.subjectmembrane depolarization
dc.subjectmolecular interaction
dc.subjectneurotransmission
dc.subjectprotein binding
dc.subjectreview
dc.subjectbrain function
dc.subjectbrain tissue
dc.subjectcell function
dc.subjectemotion
dc.subjectinformation processing
dc.subjection transport
dc.subjectlearning
dc.subjectmacromolecule
dc.subjectmemory
dc.subjectneurobiology
dc.subjectoscillation
dc.titleBiomolecular information, brain activity and cognitive functions
dc.typeOtro


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