The influence of ovariectomy, simvastatin and sodium alendronate on alveolar bone in rats

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorAnbinder, Ana Lia
dc.creatorPrado, Fernanda de Almeida
dc.creatorPrado, Marcela de Almeida
dc.creatorBalducci, Ivan
dc.creatorda Rocha, Rosilene Fernandes
dc.date2014-05-27T11:22:41Z
dc.date2016-10-25T18:24:46Z
dc.date2014-05-27T11:22:41Z
dc.date2016-10-25T18:24:46Z
dc.date2007-12-01
dc.date.accessioned2017-04-06T01:28:16Z
dc.date.available2017-04-06T01:28:16Z
dc.identifierBrazilian Oral Research, v. 21, n. 3, p. 247-252, 2007.
dc.identifier1806-8324
dc.identifier1807-3107
dc.identifierhttp://hdl.handle.net/11449/70091
dc.identifierhttp://acervodigital.unesp.br/handle/11449/70091
dc.identifier10.1590/S1806-83242007000300010
dc.identifierS1806-83242007000300010
dc.identifier2-s2.0-39049149434.pdf
dc.identifier2-s2.0-39049149434
dc.identifier0000-0003-3930-4274
dc.identifierhttp://dx.doi.org/10.1590/S1806-83242007000300010
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/891239
dc.descriptionBisphosphonates are currently used in the treatment of many diseases involving increased bone resorption such as osteoporosis. Statins have been widely used for the treatment of hypercholesterolemia and recent studies have shown that these drugs are also capable of stimulating bone formation. The purpose of this study was to evaluate thel influence of an estrogen deficient state and the effects of simvastatin and sodium alendronate therapies on alveolar bone in female rats. Fifty-four rats were either ovariectomized (OVX) or sham operated. A month later, the animals began to receive a daily dose of simvastatin (SIN - 25 mg/kg), sodium alendronate (ALN - 2 mg/kg) or water (control) orally. Thirty-five days after the beginning of the treatment, the rats were sacrificed and their left hemimandibles were removed and radiographed using digital X-ray equipment. The alveolar radiographic density under the first molar was determined with gray-level scaling and the values were submitted to analysis of variance (α = 5%). Ovariectomized rats gained more weight (mean ± standard deviation: 20.06 ± 6.68%) than did the sham operated animals (12.13 ± 5.63%). Alveolar radiographic density values, expressed as gray levels, were lowest in the OVX-water group (183.49 ± 6.47), and differed significantly from those observed for the groups receiving alendronate (sham-ALN: 193.85 ± 3.81; OVX-ALN: 196.06 ± 5.11) and from those of the sham-water group (193.66 ± 4.36). Other comparisons between groups did not show significant differences. It was concluded that the ovariectomy reduced alveolar bone density and that alendronate was efficient for the treatment of this condition.
dc.languageeng
dc.relationBrazilian Oral Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAlendronate
dc.subjectModels, animal
dc.subjectOsteoporosis
dc.subjectOvariectomy
dc.subjectSimvastatin
dc.subjectalendronic acid
dc.subjectantilipemic agent
dc.subjectbone density conservation agent
dc.subjectestrogen
dc.subjecthydroxymethylglutaryl coenzyme A reductase inhibitor
dc.subjectsimvastatin
dc.subjectanalysis of variance
dc.subjectanimal
dc.subjectbone density
dc.subjectdisease model
dc.subjectdrug effect
dc.subjectdrug screening
dc.subjectfemale
dc.subjecthypercholesterolemia
dc.subjectjaw
dc.subjectmandible
dc.subjectosteolysis
dc.subjectosteoporosis
dc.subjectovariectomy
dc.subjectrandomization
dc.subjectrat
dc.subjectWistar rat
dc.subjectAlveolar Bone Loss
dc.subjectAlveolar Process
dc.subjectAnalysis of Variance
dc.subjectAnimals
dc.subjectAntilipemic Agents
dc.subjectBone Density
dc.subjectBone Density Conservation Agents
dc.subjectDisease Models, Animal
dc.subjectDrug Evaluation, Preclinical
dc.subjectEstrogens
dc.subjectFemale
dc.subjectHydroxymethylglutaryl-CoA Reductase Inhibitors
dc.subjectHypercholesterolemia
dc.subjectMandible
dc.subjectRandom Allocation
dc.subjectRats
dc.subjectRats, Wistar
dc.titleThe influence of ovariectomy, simvastatin and sodium alendronate on alveolar bone in rats
dc.typeOtro


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