Effects of fibrin sealer and resorbable gelatin on the repair of osseous defects in rat tibia

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorBalducci, Eleny Baducci
dc.creatorViola, Naiana Vianna
dc.creatorGaspar, Ana Maria Minarelli
dc.date2014-05-27T11:22:41Z
dc.date2016-10-25T18:24:46Z
dc.date2014-05-27T11:22:41Z
dc.date2016-10-25T18:24:46Z
dc.date2007-12-01
dc.date.accessioned2017-04-06T01:28:13Z
dc.date.available2017-04-06T01:28:13Z
dc.identifierBrazilian Oral Research, v. 21, n. 3, p. 222-227, 2007.
dc.identifier1806-8324
dc.identifier1807-3107
dc.identifierhttp://hdl.handle.net/11449/70088
dc.identifierhttp://acervodigital.unesp.br/handle/11449/70088
dc.identifier10.1590/S1806-83242007000300006
dc.identifierS1806-83242007000300006
dc.identifier2-s2.0-39049090922.pdf
dc.identifier2-s2.0-39049090922
dc.identifierhttp://dx.doi.org/10.1590/S1806-83242007000300006
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/891236
dc.descriptionGelfoam® - a biologically resorbable gelatin sponge - has the function of restricting hemorrhage, providing platelet rupture, and supporting fibrin threads. Beriplast® - a fibrinogen-thrombin compound - is used to adhere tissues, to consolidate sutures and in hemostasis. The objective of this study was to perform a histological analysis of the effects of haemostatic agents on osseous repair. These materials were inserted into surgical sites in young rat right and left tibiae. After the observation periods of 7, 14, 30 and 45 days, according to the bioethic protocol, the animals were killed, the tibiae were removed and fixed in 10% formalin and decalcified in equal parts of formic acid and sodium citrate solutions. After routine processing, the specimens were embedded in paraffin for microtomy. Analysis of the results demonstrated that the haemostatic agents are effective in controlling hemorrhage; they stimulate osteogenesis, featuring a pattern of osseous tissue formation similar to the control pattern, although the amount of osseous trabeculae was superior, especially in the Gelfoam group in the periods of 7 and 14 days; 30 days after surgery, the delay in tissue healing in the control group in relation to the experimental groups started to decrease, and the control and experimental groups exhibited similar tissue repair after 45 days, when all the groups exhibited secondary osseous tissue.
dc.languageeng
dc.relationBrazilian Oral Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectFibrin foam
dc.subjectFibrin tissue adhesive
dc.subjectOsteogenesis
dc.subjectRats
dc.subjectTibia
dc.subjectfibrin glue
dc.subjectgelatin
dc.subjectgelatin sponge
dc.subjectanimal
dc.subjectbone
dc.subjectbone development
dc.subjectbone prosthesis
dc.subjectdrug effect
dc.subjectdrug screening
dc.subjectpathology
dc.subjectrat
dc.subjecttibia
dc.subjectultrastructure
dc.subjectwound healing
dc.subjectAnimals
dc.subjectBone and Bones
dc.subjectBone Substitutes
dc.subjectDrug Evaluation, Preclinical
dc.subjectFibrin Tissue Adhesive
dc.subjectGelatin
dc.subjectGelatin Sponge, Absorbable
dc.subjectWound Healing
dc.titleEffects of fibrin sealer and resorbable gelatin on the repair of osseous defects in rat tibia
dc.typeOtro


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