Use of fibrin glue derived from snake venom in the repair of deep corneal ulcers - Experimental study in dogs (Canis familiaris, Linnaeus, 1758)

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorSampaio, Renato Linhares
dc.creatorRanzani, José Joaquim Titton
dc.creatorBrandão, Claudia Valeria Seullner
dc.creatorThomazini-Santos, I. A.
dc.creatorBarraviera, B.
dc.creatorBarraviera, S. R. C. S.
dc.creatorMendes Giannini, Maria José Soares
dc.date2014-05-27T11:22:41Z
dc.date2016-10-25T18:24:45Z
dc.date2014-05-27T11:22:41Z
dc.date2016-10-25T18:24:45Z
dc.date2007-12-01
dc.date.accessioned2017-04-06T01:28:11Z
dc.date.available2017-04-06T01:28:11Z
dc.identifierJournal of Venomous Animals and Toxins Including Tropical Diseases, v. 13, n. 4, p. 857-873, 2007.
dc.identifier1678-9199
dc.identifierhttp://hdl.handle.net/11449/70083
dc.identifierhttp://acervodigital.unesp.br/handle/11449/70083
dc.identifier10.1590/S1678-91992007000400014
dc.identifierS1678-91992007000400014
dc.identifierWOS:000251325200014
dc.identifier2-s2.0-38349158652.pdf
dc.identifier2-s2.0-38349158652
dc.identifier0000-0002-8059-0826
dc.identifierhttp://dx.doi.org/10.1590/S1678-91992007000400014
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/891232
dc.descriptionFibrin glue has been researched as an alternative method for tissue synthesis and is known for its capability to promote hemostasis at the application site, good approximation of wound edges and fast healing. The current study consisted in the application of fibrin glue derived from snake venom as treatment for experimental corneal ulcers. Twenty-one dogs had their corneas experimentally prepared through lamellar keratectomy (of standardized diameter and depth). Animals were divided into seven groups of three animals each. Six experimental groups were periodically evaluated and collection was carried out on the 1st, 3rd, 7th, 15 th, 30th and 60th post-operative days, whereas one control group was evaluated throughout the experiment. Analyses consisted in the clinical evolution and in the histopathological study of all operated on eyes. Results indicated that fibrin glue was efficient in repairing keratectomy wounds in dogs and contributed to an earlier healing phenomenon, avoiding edema formation and keeping corneal clearness. The use of fibrin glue derived from snake venom showed to be easy to apply, feasible with animal models and of low cost, avoiding the lesion progress and allowing fast and appropriate corneal healing.
dc.languageeng
dc.relationJournal of Venomous Animals and Toxins Including Tropical Diseases
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCornea
dc.subjectCorneal ulcer
dc.subjectFibrin glue
dc.subjectKeratoplasty
dc.subjectSnake venom
dc.subjectAnimalia
dc.subjectCanis familiaris
dc.titleUse of fibrin glue derived from snake venom in the repair of deep corneal ulcers - Experimental study in dogs (Canis familiaris, Linnaeus, 1758)
dc.typeOtro


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