Separation of the toxic zierin from Zollernia ilicifolia by high speed countercurrent chromatography

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorCoelho, R. G.
dc.creatorCalvo, T. R.
dc.creatorSantos, Lourdes Campaner dos
dc.creatorDi Stasi, L. C.
dc.creatorVilegas, Wagner
dc.date2014-05-27T11:22:38Z
dc.date2016-10-25T18:24:29Z
dc.date2014-05-27T11:22:38Z
dc.date2016-10-25T18:24:29Z
dc.date2007-11-01
dc.date.accessioned2017-04-06T01:27:11Z
dc.date.available2017-04-06T01:27:11Z
dc.identifierRevista Brasileira de Plantas Medicinais, v. 9, n. 4, p. 39-43, 2007.
dc.identifier1516-0572
dc.identifierhttp://hdl.handle.net/11449/69965
dc.identifierhttp://acervodigital.unesp.br/handle/11449/69965
dc.identifier2-s2.0-38549164786.pdf
dc.identifier2-s2.0-38549164786
dc.identifierhttp://www.ibb.unesp.br/Home/Departamentos/Botanica/RBPM-RevistaBrasileiradePlantasMedicinais/artigo7_v9_n4.pdf
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/891128
dc.descriptionPreliminary pharmacological assays of the 70% methanol extract from the leaves of the Brazilian medicinal plant Zollernia ilicifolia Vog. (Fabaceae) showed analgesic and antiulcerogenic effects. Previous analyses have shown that this extract contains, besides flavonoid glycosides and saponins, a toxic cyanogenic glycoside. Flavonoids and saponins are compounds reported in literature with antiulcerogenic activity. In this work, we developed a methodology to separate the cyanogenic glycoside from these compounds in order to obtain enough amount of material to perform pharmacological assays. The cyanogenic glycoside zierin (2S)-β-D-glucopyranosyloxy-(3-hydroxy-phenyl)- acetonitrile was separated from the other components by high speed countercurrent chromatography (HSCCC). The solvent system used was composed of chloroform-methanol-n-propanol-water (5:6:1:4, v/v/v/v). This technique led to the separation of zierin from the possible active compounds of Zollernia ilicifolia.
dc.languageeng
dc.relationRevista Brasileira de Plantas Medicinais
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHigh-speed counter-current chromatography
dc.subjectZierin
dc.subjectZollernia ilicifolia
dc.subjectchloroform
dc.subjectflavonoid
dc.subjectglycoside
dc.subjectmethanol
dc.subjectplant extract
dc.subjectpropanol
dc.subjectsaponin derivative
dc.subjectsolvent
dc.subjectunclassified drug
dc.subjectwater
dc.subjectzierin
dc.subjectzollernia ilicifolia extract
dc.subjectchromatography
dc.subjectdrug structure
dc.subjecthigh performance liquid chromatography
dc.subjecthigh speed countercurrent chromatography
dc.subjectlegume
dc.subjectmedicinal plant
dc.subjectseparation technique
dc.subjectthin layer chromatography
dc.subjectFabaceae
dc.subjectZollernia
dc.titleSeparation of the toxic zierin from Zollernia ilicifolia by high speed countercurrent chromatography
dc.typeOtro


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