| dc.contributor | Universidade Estadual Paulista (UNESP) | |
| dc.creator | Ferraz, Lucieni C.B. | |
| dc.creator | Schellini, Silvana Artioli | |
| dc.creator | Marques, Mariângela Esther Alencar | |
| dc.date | 2014-05-27T11:22:27Z | |
| dc.date | 2016-10-25T18:23:46Z | |
| dc.date | 2014-05-27T11:22:27Z | |
| dc.date | 2016-10-25T18:23:46Z | |
| dc.date | 2007-04-01 | |
| dc.date.accessioned | 2017-04-06T01:24:29Z | |
| dc.date.available | 2017-04-06T01:24:29Z | |
| dc.identifier | International Journal of Ophthalmology, v. 7, n. 2, p. 291-293, 2007. | |
| dc.identifier | 1672-5123 | |
| dc.identifier | http://hdl.handle.net/11449/69616 | |
| dc.identifier | http://acervodigital.unesp.br/handle/11449/69616 | |
| dc.identifier | 2-s2.0-34248579599.pdf | |
| dc.identifier | 2-s2.0-34248579599 | |
| dc.identifier | http://www.ijo.cn/en_publish/2009/3/200903002.pdf | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/890835 | |
| dc.description | • Aim: To observe the effects of topical application of 5-fluorouracil (5-FU) on the rabbits corneal limbus. • Methods: 5-FU was applied topically to the corneoscleral region of rabbits eyes. The animals were sacrificed immediately or 7, 15, 30 and 60 days later, and tissues were submitted to histological examination. • Results: All animals presented corneoscleral deepithelization close to the site of application during the immediate post-operative period, whereas on the 4th postoperative day ulceration was no longer present. Histological examination showed absence of epithelium and slight edema. After one week (G2), 2 animals presented epithelial defects, thickened epithelium with larger basal cells and loose chromatin, and slight subepithelial edema. The remaining groups showed no alterations. • Conclusion: The 5-FU topically on the corneoscleral limbus postpone the epitelization. | |
| dc.language | eng | |
| dc.relation | International Journal of Ophthalmology | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | 5-fluorouracil | |
| dc.subject | Antimitotic agent | |
| dc.subject | Histopathology | |
| dc.subject | Rabbits | |
| dc.subject | Topical application | |
| dc.subject | fluorouracil | |
| dc.subject | animal experiment | |
| dc.subject | animal model | |
| dc.subject | animal tissue | |
| dc.subject | controlled study | |
| dc.subject | cornea edema | |
| dc.subject | cornea epithelium | |
| dc.subject | cornea limbus | |
| dc.subject | drug effect | |
| dc.subject | histology | |
| dc.subject | nonhuman | |
| dc.subject | postoperative period | |
| dc.subject | rabbit | |
| dc.title | Effect of topical application of 5-FU on the corneoscleral limbus of rabbits | |
| dc.type | Otro | |
