Comparison between polyurethanes containing castor oil (Soft Segment) and cancellous bone autograft in the treatment of segmental bone defect induced in rabbits

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorPereira-Júnior, Oduvaldo Câmara Marques
dc.creatorRahal, Sheila Canevese
dc.creatorIamaguti, Paulo
dc.creatorFelisbino, Luis Sérgio
dc.creatorPavan, Teodoro Priscila
dc.creatorVulcano, Luiz Carlos
dc.date2014-05-27T11:22:22Z
dc.date2016-10-25T18:23:26Z
dc.date2014-05-27T11:22:22Z
dc.date2016-10-25T18:23:26Z
dc.date2007-01-01
dc.date.accessioned2017-04-06T01:23:16Z
dc.date.available2017-04-06T01:23:16Z
dc.identifierJournal of Biomaterials Applications, v. 21, n. 3, p. 283-297, 2007.
dc.identifier0885-3282
dc.identifier1530-8022
dc.identifierhttp://hdl.handle.net/11449/69450
dc.identifierhttp://acervodigital.unesp.br/handle/11449/69450
dc.identifier10.1177/0885328206063526
dc.identifier2-s2.0-33846147968
dc.identifier0000-0002-9211-4093
dc.identifierhttp://dx.doi.org/10.1177/0885328206063526
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/890700
dc.descriptionThe aim of this study is to compare polyurethanes containing castor oil (soft segment) in granular form compared to cancellous bone autograft applied to a segmental bone defect. Norfolk adult female rabbits - approximately 13 months of age with a mean body weight of 4.5 kg - are used. In both radial diaphyses, 1 cm osteoperiosteal segmental defects are created. The defect in the left radius is filled with the castor-oil-based polyurethane, and the right one, filled with cancellous bone autograft, collected from the left proximal humerus. The rabbits are euthanazed at 15, 30, 60, and 120 days postsurgery (5 animals/ period), for histological analyses. By radiographic analyses, at these time points, the bone regeneration is more evident and accelerated in the bone defects treated with the cancellous bone autograft. At 120 days postsurgery, the segmental bone defects treated with the cancellous bone autograft are totally reconstituted and remodeled, while the bone defects treated with polyurethane polymer have bone formation of 79%. Histological study shows that the polyurethane acts as a space filler, minimizing the local production of fibrous tissue. No granule degradation, resorption or any inflammatory reaction is detected. Thus, it is possible to conclude that the castor-oil-plant-based polyurethane - in the granule presentation - is biocompatible and osteointegrated, but does not show the same bone regeneration capacity as the cancellous bone autograft. © 2007 SAGE Publications.
dc.languageeng
dc.relationJournal of Biomaterials Applications
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBiomaterial
dc.subjectBone
dc.subjectPolyurethane
dc.subjectSegmental bone defect
dc.subjectBiopolymers
dc.subjectDefects
dc.subjectHistology
dc.subjectRadiography
dc.subjectCancellous bone autograft
dc.subjectCastor oil
dc.subjectRadiographic analyses
dc.subjectPolyurethanes
dc.subjectcastor oil
dc.subjectpolyurethan
dc.subjectanimal
dc.subjectautotransplantation
dc.subjectbone prosthesis
dc.subjectchemistry
dc.subjectcomparative study
dc.subjectfemale
dc.subjectfracture healing
dc.subjecthumerus
dc.subjectphysiology
dc.subjectrabbit
dc.subjectradiography
dc.subjectradius fracture
dc.subjecttransplantation
dc.subjecttreatment outcome
dc.subjectAnimals
dc.subjectBone Substitutes
dc.subjectCastor Oil
dc.subjectFemale
dc.subjectFracture Healing
dc.subjectHumerus
dc.subjectRabbits
dc.subjectRadius Fractures
dc.subjectTransplantation, Autologous
dc.subjectTreatment Outcome
dc.titleComparison between polyurethanes containing castor oil (Soft Segment) and cancellous bone autograft in the treatment of segmental bone defect induced in rabbits
dc.typeOtro


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