In situ expression of mononuclear cell markers and interleukin-2 receptor in renal allograft biopsies of acute rejection and borderline cases

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorRodrigues, Fernanda M. D.
dc.creatorDe Carvalho, Maria Fernanda C.
dc.creatorFranchi, Marcos R.
dc.creatorGandin, Celene M. C.
dc.creatorViero, Rosa Marlene
dc.date2014-05-27T11:22:22Z
dc.date2016-10-25T18:23:25Z
dc.date2014-05-27T11:22:22Z
dc.date2016-10-25T18:23:25Z
dc.date2007-01-01
dc.date.accessioned2017-04-06T01:23:13Z
dc.date.available2017-04-06T01:23:13Z
dc.identifierRenal Failure, v. 29, n. 1, p. 29-35, 2007.
dc.identifier0886-022X
dc.identifier1525-6049
dc.identifierhttp://hdl.handle.net/11449/69443
dc.identifierhttp://acervodigital.unesp.br/handle/11449/69443
dc.identifier10.1080/08860220601038306
dc.identifier2-s2.0-33846951495
dc.identifierhttp://dx.doi.org/10.1080/08860220601038306
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/890693
dc.descriptionThe correct diagnosis of renal allograft rejection may be difficult using only clinical and/or histopathological criteria. Immunological assays should be considered in order to evaluate the phenotype of inflammatory infiltrate in renal allograft biopsies. Immunohistochemical studies were performed to detect mononuclear cells, CD4 and CD8 T lymphocytes, B lymphocytes, macrophages, null cells, and positive cells for interleukin-2 receptors. A total of 41 allograft biopsies classified into three groups were studied: acute cellular rejection (28 biopsies/22 patients), borderline (7 biopsies/5 patients) and control (6 biopsies/6 patients). In the rejection group (RG), increased cellularity was found mainly at the tubulo-interstitial level. Expression of CD8 positive cells was higher in RG when compared to borderline (BG) and control (CG) groups, respectively (0.9 vs. 0.0 vs. 0.35 cells/mm2; p < 0.001). Expression of macrophages was not statistically significant among the three groups (RG = 0.6 vs. BG = 0.2 vs. CG = 0.0 cells/mm2; p < 0.02). In the BG, CD4 + cells predominated (BG = 0.2 vs. RG = 0.05 vs. CG = 0.0 cells/mm2; p < 0.05). Clinically these patients were treated as cases of acute rejection. The numbers and different types of infiltrating cells did not correlate with patient's clinical outcome. Copyright © Informa Healthcare.
dc.languageeng
dc.relationRenal Failure
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCells typing
dc.subjectMorphometry
dc.subjectRejection
dc.subjectRenal allograft
dc.subjectcell marker
dc.subjectinterleukin 2 receptor
dc.subjectadolescent
dc.subjectadult
dc.subjectaged
dc.subjectB lymphocyte
dc.subjectbiopsy
dc.subjectCD4+ T lymphocyte
dc.subjectCD8+ T lymphocyte
dc.subjectcell count
dc.subjectcell infiltration
dc.subjectcell type
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectfemale
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectimmunohistochemistry
dc.subjectkidney allograft
dc.subjectkidney graft rejection
dc.subjectmacrophage
dc.subjectmale
dc.subjectmononuclear cell
dc.subjectnull cell
dc.subjectoutcome assessment
dc.subjectpriority journal
dc.subjectstatistical significance
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAntigens, CD
dc.subjectBiological Markers
dc.subjectBiopsy
dc.subjectFemale
dc.subjectGraft Rejection
dc.subjectHumans
dc.subjectKidney
dc.subjectKidney Transplantation
dc.subjectLeukocytes, Mononuclear
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPhenotype
dc.subjectReceptors, Interleukin-2
dc.titleIn situ expression of mononuclear cell markers and interleukin-2 receptor in renal allograft biopsies of acute rejection and borderline cases
dc.typeOtro


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