Risk of peritonitis during peritoneal dialysis in carriers of Staphylococcus aureus and coagulase-negative staphylococci

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorBatalha, J. E N
dc.creatorCaramori, J. C T
dc.creatorCorrente, J. E.
dc.creatorMontelli, A. C.
dc.creatorBarretti, Pasqual
dc.creatorCunha, Maria de Lourdes Ribeiro de Souza da
dc.date2014-05-27T11:22:01Z
dc.date2016-10-25T18:22:55Z
dc.date2014-05-27T11:22:01Z
dc.date2016-10-25T18:22:55Z
dc.date2006-11-01
dc.date.accessioned2017-04-06T01:21:17Z
dc.date.available2017-04-06T01:21:17Z
dc.identifierJournal of Venomous Animals and Toxins Including Tropical Diseases, v. 12, n. 4, p. 578-594, 2006.
dc.identifier1678-9199
dc.identifierhttp://hdl.handle.net/11449/69206
dc.identifierhttp://acervodigital.unesp.br/handle/11449/69206
dc.identifier10.1590/S1678-91992006000400005
dc.identifierS1678-91992006000400005
dc.identifierWOS:000246282100005
dc.identifier2-s2.0-33846283809.pdf
dc.identifier2-s2.0-33846283809
dc.identifier0000-0001-5478-4996
dc.identifierhttp://dx.doi.org/10.1590/S1678-91992006000400005
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/890475
dc.descriptionThe presence of Staphylococcus aureus in the nasal cavities and pericatheter skin of peritoneal dialysis patients put them at high risk of developing peritonitis. However, it is not clear whether the presence of coagulase-negative staphylococci (CNS) in the nasal passages and skin of patients is related to subsequent occurrence of peritoneal infection. The aim of the present study was to verify the relationship between endogenous sources of S. aureus and CNS and occurrence of peritonitis in patients undergoing peritoneal dialysis. Thirty-two patients on peritoneal hemodialysis were observed for 18 months. Staphylococcus species present in their nasal passage, pericatheter skin and peritoneal effluent were identified and compared based on drug susceptibility tests and dendrograms, which were drawn to better visualize the similarity among strains from extraperitoneal sites as well as their involvement in the causes of infection. Out of 288 Staphylococcus strains isolated, 155 (53.8%) were detected in the nasal cavity, 122 (42.4%) on the skin, and 11 (3.8%) in the peritoneal effluent of patients who developed peritonitis during the study. The most frequent Staphylococcus species were CNS (78.1%), compared with S. aureus (21.9%). Among CNS, S. epidermidis was predominant (64.4%), followed by S. warneri (15.1%), S. haemolyticus (10.7%), and other species (9.8%). Seven (64%) out of 11 cases of peritonitis analyzed presented similar strains. The same strain was isolated from different sites in two (66%) out of three S. aureus infection cases. In the six cases of S. epidermidis peritonitis, the species that caused infection was also found in the normal flora. From these, two cases (33%) presented highly similar strains and in three cases (50%), it was difficult to group strains as to similarity. Patients colonized with multidrug-resistant S. epidermidis strains were more predisposed to infection. Results demonstrated that an endogenous source of S. epidermidis could cause peritonitis in peritoneal dialysis patients, similarly to what has been observed with S. aureus.
dc.languageeng
dc.relationJournal of Venomous Animals and Toxins Including Tropical Diseases
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCarriers
dc.subjectCoagulase-negative staphylococci
dc.subjectPeritoneal dialysis
dc.subjectPeritonitis
dc.subjectStaphylococcus aureus
dc.subjectStaphylococcus
dc.subjectStaphylococcus epidermidis
dc.subjectStaphylococcus haemolyticus
dc.subjectStaphylococcus warneri
dc.titleRisk of peritonitis during peritoneal dialysis in carriers of Staphylococcus aureus and coagulase-negative staphylococci
dc.typeOtro


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