Prostatic stromal microenvironment and experimental diabetes

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorRibeiro, D. L.
dc.creatorCaldeira, E. J.
dc.creatorCândido, E. M.
dc.creatorManzato, A. J.
dc.creatorTaboga, Sebastião Roberto
dc.creatorAlves Cagnon, V. H.
dc.date2014-05-27T11:21:48Z
dc.date2016-10-25T18:21:52Z
dc.date2014-05-27T11:21:48Z
dc.date2016-10-25T18:21:52Z
dc.date2006-01-01
dc.date.accessioned2017-04-06T01:17:33Z
dc.date.available2017-04-06T01:17:33Z
dc.identifierEuropean Journal of Histochemistry, v. 50, n. 1, p. 421-430, 2006.
dc.identifier1121-760X
dc.identifierhttp://hdl.handle.net/11449/68748
dc.identifierhttp://acervodigital.unesp.br/handle/11449/68748
dc.identifierWOS:000236448900008
dc.identifier2-s2.0-41649103873.pdf
dc.identifier2-s2.0-41649103873
dc.identifier0000-0002-0970-4288
dc.identifierhttp://www.ejh.it/index.php/ejh/article/viewArticle/975/
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/890065
dc.descriptionThe diabetes causes alterations in various organ systems, including the male accessory sex glands. The prostate is very important in the reproductive process and it is a frequent target of malignant changes. The aim of this work was to demonstrate the histochemical and ultrastructural alterations in the prostate of diabetic animals. Two groups of animals were utilized: control and non-obese diabetic mice (NOD). Twelve days after the characterization of diabetic status the ventral prostate was collected, fixed in Karnovsky and paraformaldehyde, processed for histochemistry and TEM associated to stereology. The results showed reduction of the epithelial area and increasing of the stromal area with muscular and collagen hypertrophy in the prostatic gland. It was characterized the development of prostatic intraepithelial neoplasia, inflammatory processes and dilation of the organelles involved in the secretory process. It was concluded that diabetes besides damaging the reproductive process, affects the glandular homeostasis favoring the development of prostatic pathologies. ©2005, European Journal of Histochemistry.
dc.languageeng
dc.relationEuropean Journal of Histochemistry
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDiabetes
dc.subjectHistochemistry and ultrastructure
dc.subjectNOD mice
dc.subjectProstate
dc.subjectStroma
dc.subjectparaformaldehyde
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectcell organelle
dc.subjectcontrolled study
dc.subjectexperimental diabetes mellitus
dc.subjecthistochemistry
dc.subjecthomeostasis
dc.subjectmale
dc.subjectmouse
dc.subjectnonhuman
dc.subjectprostate
dc.subjectprostate hypertrophy
dc.subjectprostate tumor
dc.subjectstereology
dc.subjectultrastructure analysis and electron microscopy
dc.subjectAnimalia
dc.subjectMus
dc.titleProstatic stromal microenvironment and experimental diabetes
dc.typeOtro


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