Breast-cancer extracellular vesicles induce platelet activation and aggregation by tissue factor-independent and -dependent mechanisms

dc.creatorGomes, Fausto G.
dc.creatorSandim, Vanessa
dc.creatorAlmeida, Vitor H.
dc.creatorRondon, Araci M. R.
dc.creatorSuccar, Barbara B.
dc.creatorHottz, Eugenio D.
dc.creatorLeal, Ana Carolina
dc.creatorVerçoza, Brunno Renato F.
dc.creatorRodrigues, Juliany Cola F.
dc.creatorBozza, Patrícia T.
dc.creatorZingali, Russolina B.
dc.creatorMonteiro, Robson Q.
dc.date2018-05-22T19:36:09Z
dc.date2018-05-22T19:36:09Z
dc.date2017
dc.date.accessioned2023-09-27T00:16:21Z
dc.date.available2023-09-27T00:16:21Z
dc.identifierGOMES, Fausto G. et al. Breast-cancer extracellular vesicles induce platelet activation and aggregation by tissue factor-independent and -dependent mechanisms. Thrombosis Research, v.159, p.24-32, 2017.
dc.identifier0049-3848
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/26562
dc.identifier10.1016/j.thromres.2017.09.019
dc.identifier1879-2472
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8899175
dc.descriptionCancer-associated thrombosis is one of the major causes of worse prognosis among tumor-bearing patients. Extracellular vesicles derived from cancer cells, which can be divided mainly into microvesicles and exosomes, can participate in several tumor progression phenomena. Tumor-derived microvesicles positive for tissue factor (TF) have been associated with thrombotic risk in certain cancer types. Cancer cell-derived exosomes, however, have not. In this study we evaluated the capacity of extracellular vesicles (EVs, containing both microvesicles and exosomes) derived from breast-cancer cell lines in promoting platelet activation, aggregation and plasma coagulation, in experiments that access both TF-dependent and -independent activities.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsrestricted access
dc.subjectThrombosis
dc.subjectCancer
dc.subjectExtracellular vesicles
dc.subjectExosomes
dc.subjectMicrovesicles
dc.subjectPlatelets
dc.subjectExossomos
dc.subjectVesículas Extracelulares
dc.subjectTrombose
dc.subjectCâncer
dc.subjectMicropartículas Derivadas de Células
dc.subjectPlaquetas
dc.titleBreast-cancer extracellular vesicles induce platelet activation and aggregation by tissue factor-independent and -dependent mechanisms
dc.typeArticle


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