Functional polymorphisms in IL13 are protective against high Schistosoma mansoni infection intensity in a Brazilian population

dc.creatorGrant, Audrey V
dc.creatorAraujo, Maria Ilma Andrade Santos
dc.creatorPonte, Eduardo Vieira
dc.creatorOliveira, Ricardo Riccio
dc.creatorGao, Peisong
dc.creatorCruz Filho, Alvaro Augusto Souza da
dc.creatorBarnes, Kathleen C
dc.creatorBeaty, Terri H
dc.date2018-07-05T18:08:03Z
dc.date2018-07-05T18:08:03Z
dc.date2012
dc.date.accessioned2023-09-27T00:16:20Z
dc.date.available2023-09-27T00:16:20Z
dc.identifierGRANT, A. V. et al. Functional polymorphisms in IL13 are protective against high Schistosoma mansoni infection intensity in a Brazilian population. Plos One, v. 7, n. 5, p. e35863, 2012.
dc.identifier1932-6203
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/27330
dc.identifier10.1371/journal.pone.0035863
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8899172
dc.descriptionOliveira, Ricardo Riccio. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
dc.descriptionGlaxo-Smith-Kline under the project WE445 entitled ‘‘Immunogenetics of Schistosomiasis and Asthma,’’ and National Institutes of Health grant # AI050024. KCB
dc.descriptionIL-13 is a signature cytokine of the helper T cell type 2 (TH2) pathway which underlies host defense to helminthic infection and activates production of IgE in both parasitized populations and in urban settings after allergen exposure. Methodology/Principal Findings: Two functional polymorphisms in IL13, rs1800925 (or c.1-1111C.T) and rs20541 (or R130Q) were previously found to be associated with Schistosoma hematobium infection intensity. They have not been thoroughly explored in S. mansoni-endemic populations, however, and were selected along with 5 tagging SNPs for genotyping in 812 individuals in 318 nuclear families from a schistosomiasis-endemic area of Conde, Bahia, in Brazil. Regression models using GEE to account for family membership and family-based quantitative transmission disequilibrium tests (QTDT) were used to evaluate associations with total serum IgE (tIgE) levels and S. mansoni fecal egg counts adjusted for non-genetic covariates. We identified a protective effect for the T allele at rs20541 (P = 0.005) against high S. mansoni egg counts, corroborated by QTDT (P = 0.014). Our findings also suggested evidence for protective effects for the T allele at rs1800925 and A allele at rs2066960 after GEE analysis only (P = 0.050, 0.0002). Conclusions/Significance: The two functional variants in IL13 are protective against high S. mansoni egg counts. These markers showed no evidence of association with tIgE levels, unlike tIgE levels previously studied in non-parasitized or atopic study populations.
dc.formatapplication/pdf
dc.languageeng
dc.publisherPublic Library of Science
dc.rightsopen access
dc.subjectPolimorfismo
dc.subjectSchistosoma mansoni
dc.subjectPopulação
dc.subjectInfecção
dc.subjectHumanos
dc.subjectBrasil
dc.subjectPolymorphisms
dc.subjectSchistosoma mansoni
dc.subjectPopulations
dc.subjectInfection
dc.subjectHumans
dc.subjectBrazil
dc.titleFunctional polymorphisms in IL13 are protective against high Schistosoma mansoni infection intensity in a Brazilian population
dc.typeArticle


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