Chemical Composition and Anti-Trypanosoma cruzi Activity of cruzi Activity of Essential Oils Obtained from Leaves of Xylopia frutescens and X. laevigata (Annonaceae)

dc.creatorSilva, Thanany Brasil da
dc.creatorMenezes, Leociley Rocha Alencar
dc.creatorSampaio, Marília Fernanda Chaves
dc.creatorMeira, Cássio Santana
dc.creatorGuimarães, Elisalva Teixeira
dc.creatorSoares, Milena Botelho Pereira
dc.creatorPrata, Ana Paula do Nascimento
dc.creatorNogueira, Paulo Cesar de Lima
dc.creatorCosta, Emmanoel Vilaça
dc.date2016-05-11T16:37:02Z
dc.date2016-05-11T16:37:02Z
dc.date2013
dc.date.accessioned2023-09-27T00:16:08Z
dc.date.available2023-09-27T00:16:08Z
dc.identifierSILVA, T. B. et al. Chemical Composition and Anti-Trypanosoma cruzi Activity of cruzi Activity of Essential Oils Obtained from Leaves of Xylopia frutescens and X. laevigata (Annonaceae). Natural Product Communications, v. 8, n. 3, p. 403-406, 2013.
dc.identifier1934-578X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/14252
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8899137
dc.descriptionEssential oils from leaves of Xylopia frutescens (XFMJ) and two specimens of Xylopia laevigata (XLMC and XLSI) were obtained by hydrodistillation using a Clevenger-type apparatus, and analyzed by GC-MS and GC-FID. Sesquiterpenes dominated the essential oils. The main constituents of XFMJ were (E)-caryophyllene (24.8%), bicyclogermacrene (20.8%), germacrene D (17.0%), -elemene (7.9%), and (E)--ocimene (6.8%). XLMC contained significant quantities of germacrene D (18.9%), bicyclogermacrene (18.4%), -elemene (9.5%), -selinene (9.2%), (E)-caryophyllene (8.5%), germacrene B (5.7%) and -muurolene (5.7%), while germacrene D (27.0%), bicyclogermacrene (12.8%), (E)-caryophyllene (8.6%), -muurolene (8.6%), -cadinene (6.8%), and germacrene B (6.0%) were the main components of XLSI. The essential oils had trypanocidal activity against the Y strain of Trypanosoma cruzi, with IC50 values lower than 30 μg.mL-1 and 15 μg.mL-1 against epimastigote and trypomastigote forms of T. cruzi, respectively, and were also able to reduce the percentage in vitro of T. cruzi-infected macrophages and the intracellular number of amastigotes at concentrations that were non-cytotoxic to macrophages
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherNatural Product Communications
dc.rightsopen access
dc.subjectXylopia frutescens
dc.subjectXylopia laevigata
dc.subjectEssential oil
dc.subjectTrypanocidal activity
dc.titleChemical Composition and Anti-Trypanosoma cruzi Activity of cruzi Activity of Essential Oils Obtained from Leaves of Xylopia frutescens and X. laevigata (Annonaceae)
dc.typeArticle


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