Biotechnological Evolution of siRNA Molecules: From Bench Tool to the Refined Drug

dc.creatorCunha, Danielle de Brito e
dc.creatorFrederico, Ana Beatriz Teixeira
dc.creatorAzamor, Tamiris
dc.creatorMelgaço, Juliana Gil
dc.creatorNeves, Patricia Cristina da Costa
dc.creatorAno Bom, Ana Paula Dinis
dc.creatorTilli, Tatiana Martins
dc.creatorMissailidis, Sotiris
dc.date2022-07-03T14:08:35Z
dc.date2022-07-03T14:08:35Z
dc.date2022
dc.date.accessioned2023-09-27T00:15:54Z
dc.date.available2023-09-27T00:15:54Z
dc.identifierCUNHA, Danielle de Brito e etal. Biotechnological Evolution of siRNA Molecules: From Bench Tool to the Refined Drug. Pharmaceuticals, v. 15, 575, p. 1 - 21, 2022.
dc.identifier1999-4923
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/53617
dc.identifier10.3390/ph15050575
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8899103
dc.descriptionThe depth and versatility of siRNA technologies enable their use in disease targets that are undruggable by small molecules or that seek to achieve a refined turn-off of the genes for any therapeutic area. Major extracellular barriers are enzymatic degradation of siRNAs by serum endonucleases and RNAases, renal clearance of the siRNA delivery system, the impermeability of biological membranes for siRNA, activation of the immune system, plasma protein sequestration, and capillary endothelium crossing. To overcome the intrinsic difficulties of the use of siRNA molecules, therapeutic applications require nanometric delivery carriers aiming to protect double-strands and deliver molecules to target cells. This review discusses the history of siRNAs, siRNA design, and delivery strategies, with a focus on progress made regarding siRNA molecules in clinical trials and how siRNA has become a valuable asset for biopharmaceutical companies.
dc.formatapplication/pdf
dc.languageeng
dc.publisherMDPI
dc.rightsopen access
dc.subjectMedicamento personalizado
dc.subjectentrega de siRNA
dc.subjectEmpresa biofarmacêutica
dc.subjectDesempenho de siRNA em ensaios clínicos
dc.subjectPersonalized medicine
dc.subjectsiRNA delivery
dc.subjectBiopharmaceutical company
dc.subjectPerformance of siRNA in clinical trials
dc.titleBiotechnological Evolution of siRNA Molecules: From Bench Tool to the Refined Drug
dc.typeArticle


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