Resource utilization for multidrug-resistant tuberculosis household contact investigations (A5300/I2003)

dc.creatorSwindells, Susan
dc.creatorGupta, Amita
dc.creatorKim, Soyeon
dc.creatorHughes, Michael D.
dc.creatorSanchez, Jorge
dc.creatorMave, Vidya
dc.creatorDawson, Rodney
dc.creatorKumarasamy, Nagalingeswaran
dc.creatorComins, Kyla
dc.creatorSmith, Betsy
dc.creatorRustomjee, Roxana
dc.creatorNaini, Linda
dc.creatorShah, N. Sarita
dc.creatorHesseling, Anneke
dc.creatorChurchyard, Gavin
dc.creatorACTG5300/IMPAACT2003 PHOENIx Feasibility Study Team
dc.date2019-12-12T13:07:13Z
dc.date2019-12-12T13:07:13Z
dc.date2018
dc.date.accessioned2023-09-27T00:15:38Z
dc.date.available2023-09-27T00:15:38Z
dc.identifierSWINDELLS, Susan et al. Resource utilization for multidrug-resistant tuberculosis household contact investigations (A5300/I2003). International Journal of Tuberculosis and Lung Disease, v. 22, n. 9, p. 1016-1022, Sept. 2018.
dc.identifier1027-3719
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/37892
dc.identifier10.5588/ijtld.18.0163
dc.identifier1815-7920
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8899057
dc.descriptionAna Cristina Garcia Ferreira / Maria Regina Rocha. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento. (Site12101) Grant 5UM1AI069476–09.
dc.descriptionBackground: Current guidelines recommend evaluation of household contacts (HHC) of individuals with multidrug-resistant tuberculosis (MDR-TB) but widespread implementation of this policy is challenging. Objective: To describe site-level resource utilization and operational challenges encountered when identifying, recruiting, and characterizing adult MDR-TB Index Cases and their HHC. Design: Cross-sectional study of adult MDR-TB Index Cases and HHC at 16 clinical research sites in 8 countries. Site-level resource utilization was assessed using structured surveys. Results: Between October 2015 and April 2016, 308 Index Cases and 1018 HHC were enrolled. Of 280 Index Cases with sputum collected, 94 were smear positive (34%, 95% Confidence Interval (CI): 28–39%) and of 201 with chest x-rays, 87 had cavitary disease (43%, CI: 37–50%) after a mean duration of treatment of 8 weeks. Staff required 512 attempts to evaluate the 308 households, median time per attempt of 4 hours. 77% (CI: 73─80%) of the HHC were at increased risk for TB: 13% < 5 years; 8% >5 years. and HIV-infected; and 79% >5 years, HIV-/unknown and TST/IGRA positive. 121 previously undiagnosed TB cases were identified. Issues identified by site staff included complexity of personnel and participant transportation, infection control, personnel safety and management of stigma surrounding household visits. Conclusion: Household contact investigations can be high yield but are labor intensive.
dc.description2020-06-12
dc.formatapplication/pdf
dc.languageeng
dc.publisherInternational Union Against Tuberculosis and Lung Disease
dc.rightsopen access
dc.subjectMDR-TB
dc.subjectHousehold contact investigation
dc.subjectResource utilization
dc.titleResource utilization for multidrug-resistant tuberculosis household contact investigations (A5300/I2003)
dc.typeArticle


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