Performance of recombinant chimeric proteins in the serological diagnosis of Trypanosoma cruzi infection in dogs

dc.creatorLeony, Leonardo Maia
dc.creatorFreitas, Natália Erdens Maron de
dc.creatorDel-Rei, Rodrigo Pimenta
dc.creatorCarneiro, Claudia Martins
dc.creatorReis, Alexandre Barbosa
dc.creatorJansen, Ana Maria
dc.creatorXavier, Samanta Cristina das Chagas
dc.creatorGomes, Yara M.
dc.creatorSilva, Edmilson D.
dc.creatorReis, Mitermayer Galvão dos
dc.creatorFraga, Deborah Bittencourt Mothé
dc.creatorCeledon, Paola Alejandra Fiorani
dc.creatorZanchin, Nilson I. T.
dc.creatorTorres, Filipe Dantas
dc.creatorSantos, Fred Luciano Neves
dc.date2019-07-31T17:04:53Z
dc.date2019-07-31T17:04:53Z
dc.date2019
dc.date.accessioned2023-09-27T00:15:33Z
dc.date.available2023-09-27T00:15:33Z
dc.identifierLEONY, Leonardo Maia et al. Performance of recombinant chimeric proteins in the serological diagnosis of Trypanosoma cruzi infection in dogs. Plos Neglected Tropical Diseases, v. 13, n. 6, p. 1-16, 2019.
dc.identifier1935-2727
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/34541
dc.identifier10.1371/journal.pntd.0007545
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8899041
dc.descriptionGonc¸alo Moniz Institute (Research Excellence Program - PROEP/IGM, Grant: 400904/2013-6; Internal Research Support Program - PIAP Jovem+, Grant: PIAP-001/2017), and in part by the Coordination of Superior Level Staff Improvement - Brazil (CAPES, Grant PROEX 0720/2018). Brazilian National Council for Scientific and Technological Development (CNPq) and Research Support Foundation for the State of Rio de Janeiro (FAPERJ). MGR, NITZ, CMC, ABR and AMJ are research fellows of CNPq. This study was funded by Oswaldo Cruz Foundation- FIOCRUZ; Vice- Presidency of Research and Reference Laboratories (VPPLR/FIOCRUZ) for investing in our research; the European Union Seventh Framework Program Grant 223034 – ChagasEpiNet.
dc.descriptionDogs are considered sentinels in areas of Trypanosoma cruzi transmission risk to humans. ELISA is generally the method of choice for diagnosing T. cruzi exposure in dogs, but its performance substantially depends on the antigenic matrix employed. In previous studies, our group has developed four chimeric antigens (IBMP-8.1, 8.2, 8.3, and 8.4) and evaluated their potential for diagnosing T. cruzi exposure in humans. For human sera, these chimeric antigens presented superior diagnostic performances as compared to commercial tests available in Brazil, Spain, and Argentina. Therefore, in this study we have evaluated the potential of these antigenic proteins for detection of anti-T. cruzi IgG antibodies in dog sera.
dc.formatapplication/pdf
dc.languageeng
dc.publisherPublic Library of Science
dc.rightsopen access
dc.subjectTrypanosoma cruzi
dc.subjectProteinas quiméricas
dc.subjectFatores de risco
dc.subjectTransmissão
dc.subjectCães
dc.subjectDiagnóstico
dc.subjectTrypanosoma cruzi
dc.subjectChimeric Proteins
dc.subjectRisk factors
dc.subjectTransmission
dc.subjectDogs
dc.subjectDiagnosis
dc.titlePerformance of recombinant chimeric proteins in the serological diagnosis of Trypanosoma cruzi infection in dogs
dc.typeArticle


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