In vitro cytotoxic, antifungal, trypanocidal and leishmanicidal activities of acetogenins isolated from Annona cornifolia A. St. -Hil. (Annonaceae)

dc.creatorLima, Luciana Alves Rodrigues dos Santos
dc.creatorAlves, Tânia Maria de Almeida
dc.creatorZani, Carlos Leomar
dc.creatorSales Junior, Policarpo Ademar
dc.creatorRomanha, Alvaro José
dc.creatorJohann, Susana
dc.creatorCisalpino, Patrícia Silva
dc.creatorPimenta, Lúcia Pinheiro Santos
dc.creatorBoaventura, Maria Amelia Diamantino
dc.date2022-02-01T15:05:49Z
dc.date2022-02-01T15:05:49Z
dc.date2014
dc.date.accessioned2023-09-27T00:15:19Z
dc.date.available2023-09-27T00:15:19Z
dc.identifierLIMA, Luciana Alves Rodrigues dos et al. In vitro cytotoxic, antifungal, trypanocidal and leishmanicidal activities of acetogenins isolated from Annona cornifolia A. St. -Hil. (Annonaceae). An Acad Bras Cienc., vol. 86, n. 2, p, 829-839, 2014
dc.identifier0001-3765
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/50974
dc.identifier10.1590/0001-3765201420130048
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8899003
dc.descriptionAnnona cornifolia A. St. -Hil. is a small annual perennial tree found in the Brazilian savannah; their green fruit is popularly used in the treatment of ulcers. The acetogenins isolated from the seeds of Annona cornifolia previously showed to possess antioxidant activity. In continuation of our investigations on the biological activities of acetogenins, four binary mixtures and ten pure adjacent bis-tetrahydrofuran annonaceous acetogenins were evaluated: the cytotoxic (against three human tumor cell lines), antifungal (against Paracoccidioides brasiliensis), trypanocidal (against Trypanosoma cruzi) and leishmanicidal (against Leishmania amazonensis) activities. Acetogenins presented cytotoxic activity confirming their potential use in anti-cancer therapy. Regarding leishmanicidal and trypanocidal activities, an inhibition of 87% of L. amazonensis amastigotes and 100% of T. cruzi amastigotes and trypomastigotes was observed, when tested at the concentration of 20 mu g mL(-1). Moreover, six acetogenins showed more activity against all the three tested isolates of P. brasiliensis than trimethoprim-sulfamethoxazole, a drug used for treating paracoccidioidomycosis. Thus, acetogenins may be an alternative in treating a number of diseases that have a huge impact on millions of people worldwide. This paper reports for the first time the antifungal, leishmanicidal and trypanocidal activities for these acetogenins
dc.formatapplication/pdf
dc.languageeng
dc.publisherAcademia Brasileira de Ciências
dc.rightsopen access
dc.subjectAnnona cornifolia
dc.subjectAnnona cornifolia
dc.subjectAnnona cornifolia
dc.subjectcytotoxic
dc.subjectantifungal
dc.subjectleishmanicidal
dc.titleIn vitro cytotoxic, antifungal, trypanocidal and leishmanicidal activities of acetogenins isolated from Annona cornifolia A. St. -Hil. (Annonaceae)
dc.typeArticle


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