Glomeruloid hemangioma as a late manifestation of POEMS syndrome

dc.creatorAmorim, G. Moreira
dc.creatorSodré, C.
dc.creatorFalcão, E. Mastrangelo Marinho
dc.creatorCuzzi, T.
dc.creatorFernandes, R. Timbó
dc.creatorRamos-e-Silva, M.
dc.date2019-07-18T13:30:48Z
dc.date2019-07-18T13:30:48Z
dc.date2018
dc.date.accessioned2023-09-27T00:15:12Z
dc.date.available2023-09-27T00:15:12Z
dc.identifierAMORIM, Gustavo Moreira et al. Glomeruloid hemangioma as a late manifestation of POEMS syndrome. Acta Dermatovenerologica Croatica, v. 26, n. 4, p. 321-324, 2018.
dc.identifier1330-027X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/34227
dc.identifier10.1111/j.1365-2230.2008.02997.x
dc.identifier1847-6538
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8898984
dc.descriptionTullia Cuzzi. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
dc.descriptionGlomeruloid hemangiomas were first described by Chan in 1990 as a cutaneous marker of POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal proteinemia, and Skin changes). POEMS syndrome is a multisystem disease with a significant cutaneous involvement. Among its manifestations, hemangiomas are common, observed in up to one third of the patients, and, although specific, the glomeruloid subtype is very rare. The vascular endothelium growth factor (VEGF) is an angiogenic stimulation factor, which also induces increased systemic vascular permeability. Thus, a scenario of overexpression of VEGF can credibly lead to the assumption of an association between cutaneous hemangiomas and systemic manifestations, implying prognostic and therapeutic considerations and reinforcing the importance of dermatological periodical consultations for these patients. We report the case of a patient in whom glomeruloid hemangiomas marked the recurrence of POEMS syndrome, occurring before the systemic symptoms.
dc.formatapplication/pdf
dc.languageeng
dc.publisherCroatian Medical Association
dc.rightsopen access
dc.subjectPOEMS syndrome
dc.subjectGlomeruloid hemangioma
dc.subjectVascular endothelium growth factor
dc.subjectVEGF
dc.titleGlomeruloid hemangioma as a late manifestation of POEMS syndrome
dc.typeArticle


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