FUT2, Secretor Status and FUT3 Polymorphisms of Children with Acute Diarrhea Infected with Rotavirus and Norovirus in Brazil

dc.creatorTonini, Marco André Loureiro
dc.creatorBarreira, Débora Maria Pires Gonçalves
dc.creatorSantolin, Luciana Bueno de Freitas
dc.creatorVolpini, Lays Paula Bondi
dc.creatorLeite, José Paulo G.
dc.creatorLe Moullac-Vaidye, Béatrice
dc.creatorLe Pendu, Jacques
dc.creatorSpano, Liliana Cruz
dc.date2021-01-13T19:27:50Z
dc.date2021-01-13T19:27:50Z
dc.date2020
dc.date.accessioned2023-09-27T00:15:00Z
dc.date.available2023-09-27T00:15:00Z
dc.identifierTONINI, Marco André Loureiro et al. FUT2, Secretor Status and FUT3 Polymorphisms of Children with Acute Diarrhea Infected with Rotavirus and Norovirus in Brazil. Viruses, v. 12, p. 1-14, Sept. 2020.
dc.identifier1999-4915
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/45673
dc.identifier10.3390/v12101084
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8898947
dc.descriptionHost susceptibility according to human histo-blood group antigens (HBGAs) is widely known for norovirus infection, but is less described for rotavirus. Due to the variable HBGA polymorphism among populations, we aimed to evaluate the association between HBGA phenotypes (ABH, Lewis and secretor status) and susceptibility to rotavirus and norovirus symptomatic infection, and the polymorphisms of FUT2 and FUT3, of children from southeastern Brazil. Paired fecal-buccal specimens from 272 children with acute diarrhea were used to determine rotavirus/norovirus genotypes and HBGAs phenotypes/genotypes, respectively. Altogether, 100 (36.8%) children were infected with rotavirus and norovirus. The rotavirus P[8] genotype predominates (85.7%). Most of the noroviruses (93.8%) belonged to genogroup II (GII). GII.4 Sydney represented 76% (35/46) amongst five other genotypes. Rotavirus and noroviruses infected predominantly children with secretor status (97% and 98.5%, respectively). However, fewer rotavirus-infected children were Lewis-negative (8.6%) than the norovirus-infected ones (18.5%). FUT3 single nucleotide polymorphisms (SNP) occurred mostly at the T59G > G508A > T202C > C314T positions. Our results reinforce the current knowledge that secretors are more susceptible to infection by both rotavirus and norovirus than non-secretors. The high rate for Lewis negative (17.1%) and the combination of SNPs, beyond the secretor status, may reflect the highly mixed population in Brazil.
dc.formatapplication/pdf
dc.languageeng
dc.publisherMDPI
dc.rightsopen access
dc.subjectSuscetibilidade do hospedeiro
dc.subjectAntígenos do grupo histo-sangue (HBGAs)
dc.subjectNorovírus
dc.subjectRotavírus
dc.subjectPolimorfismos de FUT2 e FUT3
dc.subjectHost susceptibility
dc.subjectHisto-blood group antigens (HBGAs)
dc.subjectNorovirus
dc.subjectRotavirus
dc.subjectSecretor status
dc.subjectPolymorphisms of FUT2 and FUT3
dc.subjectLewis
dc.titleFUT2, Secretor Status and FUT3 Polymorphisms of Children with Acute Diarrhea Infected with Rotavirus and Norovirus in Brazil
dc.typeArticle


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