Phenotypic and functional features of innate and adaptive immunity as putative biomarkers for clinical status and leprosy reactions

dc.creatorCarvalho, Jairo Campos de
dc.creatorAraújo, Marcelo Grossi
dc.creatorReis, Jordana Grazziela Alves Coelho dos
dc.creatorPaschoal, Vanessa Peruhype Magalhães
dc.creatorAlvares, Cláudio Caetano
dc.creatorMoreira, Marcela de Lima
dc.creatorCarvalho, Andréa Teixeira de
dc.creatorMartins Filho, Olindo Assis
dc.creatorAraújo, Márcio Sobreira Silva
dc.date2022-08-18T16:07:51Z
dc.date2022-08-18T16:07:51Z
dc.date2018
dc.date.accessioned2023-09-27T00:14:56Z
dc.date.available2023-09-27T00:14:56Z
dc.identifierCARVALHO, Jairo Campos de et al. Phenotypic and functional features of innate and adaptive immunity as putative biomarkers for clinical status and leprosy reactions. Microb Pathog., v. 125, p. 230-239, 2018. doi: 10.1016/j.micpath.2018.09.011.
dc.identifier0882-4010
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/54717
dc.identifier10.1016/j.micpath.2018.09.011
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8898938
dc.descriptionCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO
dc.descriptionThe aim of this study was to identify phenotypic and functional biomarkers associated with distinct clinical status of leprosy or leprosy reactions. The study included tuberculoid/borderline (BB/BT/T) and lepromatous (BL/L) leprosy poles as well as Type-1 and Type-2 leprosy reactions along with healthy controls (NI). A range of peripheral blood biomarkers of innate (neutrophils - NEU and monocytes - MON) and adaptive immunity (CD4(+) and CD8(+) T-cells) were evaluated ex vivo and upon in vitro stimuli with M. leprae antigen. Data analysis allowed the selection of NEUTLR4(+) (ex vivo) and CD4(+) IL-10(+) (in vitro) as universal biomarkers increased in all leprosy patients and those exhibiting leprosy reactions. A range of biomarkers were commonly found in both poles of leprosy patients, including decreased levels of MONTGF-beta(+) (ex vivo) and increased levels of MONTNF-alpha(+) , CD4(+) TGF-beta(+) , CD8(+) TLR2(+) , CD8(+) TNF-alpha(+) , CD8(+) IL-4(+) and CD8(+) TGF-beta(+) (in vitro). Noteworthy was that MONHLA-DR+ (ex vivo) and CD8(+) IL-10(+) (in vitro) were particularly found in BL/L patients. Leprosy patients with Type-1 reaction exhibited a larger list of altered biomarkers, mainly involving activation markers (TLR2, TLR4, HLA-DR and DAF-2T) in NEU and MON along with CD4(+) and CD8(+) cells. In summary, this study provided insights about immunological features of leprosy poles and leprosy reactional episodes with putative applicability, including novel biomarkers for complementary diagnosis and future therapeutic approaches in clinical studies.
dc.formatapplication/pdf
dc.languageeng
dc.publisherAcademic Press
dc.rightsrestricted access
dc.titlePhenotypic and functional features of innate and adaptive immunity as putative biomarkers for clinical status and leprosy reactions
dc.typeArticle


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