dc.creator | Carvalho, Jairo Campos de | |
dc.creator | Araújo, Marcelo Grossi | |
dc.creator | Reis, Jordana Grazziela Alves Coelho dos | |
dc.creator | Paschoal, Vanessa Peruhype Magalhães | |
dc.creator | Alvares, Cláudio Caetano | |
dc.creator | Moreira, Marcela de Lima | |
dc.creator | Carvalho, Andréa Teixeira de | |
dc.creator | Martins Filho, Olindo Assis | |
dc.creator | Araújo, Márcio Sobreira Silva | |
dc.date | 2022-08-18T16:07:51Z | |
dc.date | 2022-08-18T16:07:51Z | |
dc.date | 2018 | |
dc.date.accessioned | 2023-09-27T00:14:56Z | |
dc.date.available | 2023-09-27T00:14:56Z | |
dc.identifier | CARVALHO, Jairo Campos de et al. Phenotypic and functional features of innate and adaptive immunity as putative biomarkers for clinical status and leprosy reactions. Microb Pathog., v. 125, p. 230-239, 2018. doi: 10.1016/j.micpath.2018.09.011. | |
dc.identifier | 0882-4010 | |
dc.identifier | https://www.arca.fiocruz.br/handle/icict/54717 | |
dc.identifier | 10.1016/j.micpath.2018.09.011 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8898938 | |
dc.description | CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO | |
dc.description | The aim of this study was to identify phenotypic and functional biomarkers associated with distinct clinical status of leprosy or leprosy reactions. The study included tuberculoid/borderline (BB/BT/T) and lepromatous (BL/L) leprosy poles as well as Type-1 and Type-2 leprosy reactions along with healthy controls (NI). A range of peripheral blood biomarkers of innate (neutrophils - NEU and monocytes - MON) and adaptive immunity (CD4(+) and CD8(+) T-cells) were evaluated ex vivo and upon in vitro stimuli with M. leprae antigen. Data analysis allowed the selection of NEUTLR4(+) (ex vivo) and CD4(+) IL-10(+) (in vitro) as universal biomarkers increased in all leprosy patients and those exhibiting leprosy reactions. A range of biomarkers were commonly found in both poles of leprosy patients, including decreased levels of MONTGF-beta(+) (ex vivo) and increased levels of MONTNF-alpha(+) , CD4(+) TGF-beta(+) , CD8(+) TLR2(+) , CD8(+) TNF-alpha(+) , CD8(+) IL-4(+) and CD8(+) TGF-beta(+) (in vitro). Noteworthy was that MONHLA-DR+ (ex vivo) and CD8(+) IL-10(+) (in vitro) were particularly found in BL/L patients. Leprosy patients with Type-1 reaction exhibited a larger list of altered biomarkers, mainly involving activation markers (TLR2, TLR4, HLA-DR and DAF-2T) in NEU and MON along with CD4(+) and CD8(+) cells. In summary, this study provided insights about immunological features of leprosy poles and leprosy reactional episodes with putative applicability, including novel biomarkers for complementary diagnosis and future therapeutic approaches in clinical studies. | |
dc.format | application/pdf | |
dc.language | eng | |
dc.publisher | Academic Press | |
dc.rights | restricted access | |
dc.title | Phenotypic and functional features of innate and adaptive immunity as putative biomarkers for clinical status and leprosy reactions | |
dc.type | Article | |