High HTLV-1 proviral load, a marker for HTLV-1 associated myelopathy/tropical spastic paraparesis, is also detected in patients with infective dermatitis associated with HTLV-1

dc.creatorPrimo, Janeusa Rita Leite
dc.creatorSiqueira, Isadora Cristina de
dc.creatorNascimento, M. C. F
dc.creatorOliveira, M. F
dc.creatorVale, Lourdes Farre
dc.creatorCarvalho Filho, Edgar Marcelino
dc.creatorBittencourt, Achilea Candida Lisboa
dc.date2012-12-07T21:31:59Z
dc.date2012-12-07T21:31:59Z
dc.date2009
dc.date.accessioned2023-09-27T00:14:31Z
dc.date.available2023-09-27T00:14:31Z
dc.identifierPRIMO, J. et al. High HTLV-1 proviral load, a marker for HTLV-1 associated myelopathy/tropical spastic paraparesis, is also detected in patients with infective dermatitis associated with HTLV-1. Brazilian Journal of Medical Biological Research, v. 42, n. 8, p. 761-764, aug. 2009.
dc.identifier0100-879X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/5941
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8898866
dc.descriptionSalvador (BA, Brazil) is an endemic area for human T-cell lymphotrophic virus type 1 (HTLV-1). The overall prevalence of HTLV-1 infection in the general population has been estimated to be 1.76%. HTLV-1 carriers may develop a variety of diseases such as adult T-cell leukemia/lymphoma, HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and infective dermatitis associated with HTLV-1 (IDH). IDH is a chronic and severe form of childhood exudative and infective dermatitis involving mainly the scalp, neck and ears. It has recently been observed that 30% of patients with IDH develop juvenile HAM/TSP. The replication of HTLV-1 has been reported to be greater in adult HAM/TSP patients than in asymptomatic HTLV-1 carriers. In the current study, the proviral load of 28 children and adolescents with IDH not associated with HAM/TSP was determined and the results were compared to those obtained in 28 HTLV-1 adult carriers and 28 adult patients with HAM/TSP. The proviral load in IDH patients was similar to that of patients with HAM/TSP and much higher than that found in HTLV-1 carriers. The high levels of proviral load in IDH patients were not associated with age, duration of illness, duration of breast-feeding, or activity status of the skin disease. Since proviral load is associated with neurological disability, these data support the view that IDH patients are at high risk of developing HAM/TSP.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectInfective dermatitis associated with HTLV-1
dc.subjectHTLV-1-associated myelopathy/tropical spastic paraparesis
dc.subjectHTLV-1 proviral loads
dc.subjectDermatite/virologia
dc.subjectVirus Linfotrópico de Células T Humanas
dc.subjectTipo 1/isolamento & purificação
dc.subjectParaparesia Espástica Tropical/virologia
dc.subjectDermatopatias Virais/virologia
dc.subjectMarcadores Biológicos/análise
dc.subjectPortador Sadio
dc.subjectDNA Viral/análise
dc.subjectProgressão da Doença
dc.subjectVirus Linfotrópico de Células T Humanas
dc.subjectTipo 1/genética
dc.subjectProvirus/genética
dc.subjectFatores de Risco
dc.subjectCarga Viral
dc.subjectAdolescente
dc.subjectAdulto
dc.subjectCriança
dc.subjectPré-Escolar
dc.subjectFeminino
dc.subjectMasculino
dc.subjectHumanos
dc.titleHigh HTLV-1 proviral load, a marker for HTLV-1 associated myelopathy/tropical spastic paraparesis, is also detected in patients with infective dermatitis associated with HTLV-1
dc.typeArticle


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