Outcome of B-Cell Acute Lymphoblastic Leukemia in Brazilian Children: Immunophenotypical, Hematological, and Clinical Evaluation

dc.creatorCézar, Rodrigo S
dc.creatorCerqueira, Bruno Antonio Veloso
dc.creatorPaz, Silvana de Souza da
dc.creatorBarbosa, Cynara Gomes
dc.creatorMoura Neto, José Pereira de
dc.creatorBarreto, José Henrique Silva
dc.creatorGonçalves, Marilda de Souza
dc.date2017-08-10T18:45:49Z
dc.date2017-08-10T18:45:49Z
dc.date2015
dc.date.accessioned2023-09-27T00:14:28Z
dc.date.available2023-09-27T00:14:28Z
dc.identifierCEZAR, R. S. et al. Outcome of B-Cell Acute Lymphoblastic Leukemia in Brazilian Children: Immunophenotypical, Hematological, and Clinical Evaluation. Journal of Pediatric Hematology/Oncology, v. 37, p. 423–428, 2015.
dc.identifier1077-4114
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/20578
dc.identifier10.1097/MPH.0000000000000358
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8898857
dc.descriptionThe aim of this study is to investigate the clinical, hematological, and immunophenotypic characteristics of Brazilian children with B-cell acute lymphoblastic leukemia (B-ALL) to identify prognostic biomarkers of the disease. Thirty-three children newly diagnosed with B-ALL were followed between March 2004 and December 2009. Information about the demographic profile, diagnosis, immunophenotype, clinical manifestations, and disease outcome were gathered from the patients' medical records. Of the 33 patients with B-ALL, 18 were male and 15 female. Eighteen patients were classified as high risk; 13 as low risk, and 2 as true low risk. The frequencies of cluster of differentiation (CD)10, CD19, and CD20 antigens were 69.7%, 81.8%, and 18.2%, respectively. Six patients (18.2%) had aberrant expression of myeloid antigens. At diagnosis, patients immunopositive for CD20 had elevated white blood cell counts (P = 0.018) and lower platelet counts (P = 0.017). The 6-year overall survival was 67.5%± 3.47%. Our results demonstrate the distinct immunophenotypic and prognostic characteristics of patients with B-ALL, which can be related to the Brazilian racial admixture. Consequently, these results will most likely aid in the selection of additional prognostic markers and their use in monitoring the clinical manifestations and treatment response among B-ALL patients.
dc.formatapplication/pdf
dc.languageeng
dc.publisherLippincott, Williams & Wilkins
dc.rightsopen access
dc.subjectLeucemia linfoblástica aguda
dc.subjectImunofenotipo
dc.subjectInfância
dc.subjectAcute lymphoblastic leukemia
dc.subjectImmunophenotype
dc.subjectChildhood
dc.titleOutcome of B-Cell Acute Lymphoblastic Leukemia in Brazilian Children: Immunophenotypical, Hematological, and Clinical Evaluation
dc.typeArticle


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